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Attributes of Extracellular Targeting of Cell Signaling in Cancer PDF
International experts present innovative therapeutic strategies to treat cancer patients and prevent disease progression. Extracellular Targeting of Cell Signaling in Cancer PDF
Extracellular Targeting of Cell Signaling in Cancer highlights innovative therapeutic strategies to treat cancer metastasis and prevent tumor progression. Currently, there are no drugs available to treat or prevent metastatic cancer other than non-selective, toxic chemotherapy. With contributions from an international panel of experts in the field, the book integrates diverse aspects of biochemistry, molecular biology, protein engineering, proteomics, cell biology, pharmacology, biophysics, structural biology, medicinal chemistry and drug development.
A large class of proteins called kinases are enzymes required by cancer cells to grow, proliferate, and survive apoptosis (death) by the immune system. Two important kinases are MET and RON which are receptor tyrosine kinases (RTKs) that initiate cell signaling pathways outside the cell surface in response to extracellular ligands (growth factors.) Both kinases are oncogenes which are required by cancer cells to migrate away from the primary tumor, invade surrounding tissue and metastasize. MET and RON reside on both cancer cells and the support cells surrounding the tumor, called the microenvironment. MET and RON are activated by their particular ligands, the growth factors HGF and MSP, respectively. Blocking MET and RON kinase activation and downstream signaling is a promising therapeutic strategy for preventing tumor progression and metastasis. Written for cancer physicians and biologists as well as drug discovery and development teams in both industry and academia, this is the first book of its kind which explores novel approaches to inhibit MET and RON kinases other than traditional small molecule kinase inhibitors. These new strategies target key tumorigenic processes on the outside of the cell, such as growth factor activation by proteases. These unique strategies have promising potential as an improved alternative to kinase inhibitors, chemotherapy, or radiation treatment.
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Illustrations of Extracellular Targeting of Cell Signaling in Cancer PDF
For students of all the branches of medicine and surgery and health professionals that aspire to be greater and better at their procedures and medications. A renowned book by those who have read it and learnt from it. Many have already ordered it and is on the way to their home. Whether you work in the USA, Canada, UK or anywhere around the world. If you are working as a health professional then this is a must read.. The most reviewed on book Extracellular Targeting of Cell Signaling in Cancer PDF is available for grabs now here on our website free. Whatever books, mainly textbooks we have in professional courses specially Medicine and surgery is a compendium in itself so understand one book you need to refer another 2-10 books. Beside this there are various other text material which needs to be mastered!! Only reference books are partially read but all other books have to be read, commanded and in fact read multiple times.
The Writers
Dr. James W. Janetka is an Associate Professor at Washington University School of Medicine, and has over 20 years of medicinal chemistry and drug discovery experience within both industry and academia. He has published 50 peer-reviewed manuscripts and holds 20 US patents in oncology and infectious disease.
Roseann Benson is a chemical engineer turned scientific writer and editor. As a consultant for Harvard and Washington University Medical Schools, she has edited and contributed to manuscripts and books that have been published by Wiley, CUP, Nature, and Science.
Proportions of Extracellular Targeting of Cell Signaling in Cancer PDF
- Identification Number : B07D1FB32Z
Publisher : Wiley; 1st edition (May 10, 2018)
Publication date : May 10, 2018
Language : English
File size : 18084 KB
Text-to-Speech : Enabled
Enhanced typesetting : Enabled
X-Ray : Not Enabled
Word Wise : Not Enabled
Print length : 427 pages
Lending : Enabled
Reviews From Customers
Helen4713
Very good information and easy to follow
August 28, 2018
Very good
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Dbryan1
Great item!
September 4, 2019
Cheaper than the used books at my college bookstore. Great value.
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Edwin McKetney
Very informative
August 20, 2018
As someone not trained in information technology, it was a good introduction to its crossover with population health. Great overview.
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