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Viruses Plagues and History PDF

Features of Viruses Plagues and History PDF

Viruses Plagues and History PDF-The story of viruses and humanity is a story of fear and ignorance, of grief and heartbreak, and of great bravery and sacrifice. Michael Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented humanity, focusing mostly on the most famous
Oldstone begins with smallpox, polio, and measles. Nearly 300 million people were killed by smallpox in this century alone and the author presents a vivid account of the long campaign to eradicate this lethal killer. Oldstone then describes the fascinating viruses that have captured headlines
in more recent years: Ebola, Hantavirus, mad cow disease (a frightening illness made worse by government mishandling and secrecy), and, of course, AIDS. And he tells us of the many scientists watching and waiting even now for the next great plague, monitoring influenza strains to see whether the
deadly variant from 1918–a viral strain that killed over 20 million people in 1918-1919–will make a comeback. For this revised edition, Oldstone includes discussions of new viruses like SARS, bird flu, virally caused cancers, chronic wasting disease, and West Nile, and fully updates the original
text with new findings on particular viruses.
Viruses, Plagues, and History paints a sweeping portrait of humanity’s long-standing conflict with our unseen viral enemies. Oldstone’s book is a vivid history of a fascinating field, and a highly reliable dispatch from an eminent researcher on the front line of this ongoing campaign.

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Description of Viruses Plagues and History PDF

Viruses Plagues and History PDF is one of the best medical books for students and professionals on the subject of Infectious Diseases. It is a must download.

The Authors

Viruses Plagues and History PDF

Michael Oldstone

Professor Emeritus
Department of Immunology and Microbiology
California Campus

The principle objectives of this laboratory are to understand how and what diseases are caused by acute and persistent virus infections and the role the immune response plays in protection against or causation of the disease. Included are studies on how viruses escape from immune recognition and attack to establish a persistent infection. Our focus is primarily on how virus affects the immune and central nervous systems. To understand these events we use molecular, cell biologic, and genetic approaches for analysis of virus virulence and host susceptibility. We study how viruses cause immunosuppression on one hand and autoimmunity and cytokine storm on the other.

*Pioneered the development of the field of viral pathogenesis and has been a leader in the area of viral immunity for the past four decades.

*Known for work studying arenaviruses, specifically lymphocytic choriomeningitis virus infection in its natural murine host as a model system and the pathogenesis, innate and immune response to African hemorrhagic viruses Lassa and Ebola. In addition, investigations of measles virus and cytokine storm with influenza virus.

*Provided evidence for the concept of viral-induced immunopathology by showing that chronically infected hosts can mount a humoral and cellular immune response to persistent viral infection and such hosts infected early in life were not tolerant to the infecting microbe.

*Showed that persistently infecting viruses can non-cytolytically alter the differentiation or “luxury” function of cells without killing them, leading to a disorder in homeostasis and disease of the nervous, immunologic, and endocrine systems. This is a departure from existing dogma that viral diseases reflected destruction of infected cells.

*Provided the evidence and concept for virus-induced autoimmune disease caused by cross-reactive molecular mimics between microbe and host sequences leading to antibody or T cell-induced disease.

*Isolated and characterized immunosuppressive viral variants that co-op host generated negative regulators of the immune response (NIR) that function to keep the immune response in check so it does not harm healthy tissues. By hijacking immunodominant NIR, IL-10 and PD-L1, T cells become exhausted. IFN-1 made within the first 12-18 hrs. of infection by immunosuppressive virus variants was the master regulator of IL-10 and PD-L1, and the disorganizer of secondary lymphoid organs, mechanisms responsible for viral persistence.

*Dissected role of various type 1 interferons in causation or prevention of disease.


M.D. (Medicine), University of Maryland, College Park, School of Medicine, 1961
Ph.D. (Biochemistry), Johns Hopkins University, Pratt Institute of Biochemistry, 1959
B.A. (English and History), The University of Alabama (Tuscaloosa), 1954

Dimensions and Characteristics of Viruses Plagues and History PDF

  • Publisher ‏ : ‎ Oxford University Press; Revised edition (November 2, 2009)
  • Language ‏ : ‎ English
  • Paperback ‏ : ‎ 383 pages
  • International Standard Book Number-10 ‏ : ‎ 0195327314
  • International Standard Book Number-13 ‏ : ‎ 978-0195327311
  • Item Weight ‏ : ‎ 14.8 ounces
  • Dimensions ‏ : ‎ 8.1 x 5.4 x 1.2 inches
  • Book Name : Viruses Plagues and History PDF

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Top reviews

Susan Martin “I highly recommend purchasing this book. It is very difficult to put it down when you start reading it. This writer has done an excellent job documenting in detail many of the killer viruses that have affected the world and how politics and religion impeded the success of diagnosing and treating the patients who suffered. It was intriguing to read the stories of people throughout history who treated these patients and the many personal accounts of people and events that explain in interesting detail about the ones who lived and the ones who died. You will have a much better understanding of killer viruses and become versed on the history of the diagnoses and treatment. Don’t hesitate purchasing this book if it is available. You will be pleased and it will greatly expand your knowledge if you are in the medical profession or not. It is very easy to read and understand for anyone despite their background.”

Johnny Beans “Update: I’m just about done reading this book. Here’s a quotation:

P 278. “When scientific research interferes with politics, economics, or culture, science is most often the loser. Thus, governments and businesses control health care for personal gains or concepts and disregard or avoid factual knowledge and events.” Sound familiar? This was written ten years ago. I understand that the last thing many people want is more virus talk, but this book is very informative and may effect many of your actions. It also provides a long view on identifying and treating viruses. For example, I didn’t know that it took over forty years for an effective polio vaccine. Same thing for measles. And still no vaccine for HIV fifty years into it. Hmm…


Describes different virus related plagues over the years and what we did about them. Very informative under present circumstances. Author is very knowledgeable and not pedantic although he is willing to express an opinion without beating you over the head. Well written. Both tone and content reminded me of the way Dr. Fauci talks about stuff.
Highly recommended.”

Photoguy41 “I am a retired microbiologist and do enjoy reading history books on science. The first two chapters had a pretty good review of how the immune system works. But, just a caution, might be too technical for many. However, just skip over to the first chapter on Smallpox and all is well. Well-researched; explanations are good, especially all of the history. Lots of sourcess.”
Kayla “I haven’t finished this book yet (it is my daily metro-commute read) but I am extremely pleased with the writing and subjects. Although I am not a virologist, I have always found biology, epidemiology, and medical history to be interesting and this book hits all those points and then some. I would not recommend it to the casual, non-medical reader, but I would definitely recommend it to anyone interested in medical history and science.”


Reference: Wikipedia

Viruses Plagues and History PDF

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