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Lifespan Why We Age PDF

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Lifespan Why We Age PDF-“Brilliant and enthralling.”​ —The Wall Street Journal

A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people.

It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan?

In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.”

This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger.

Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

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Description of Lifespan Why We Age PDF

Lifespan Why We Age PDF is one of the best-known books on the subject of basic medical sciences. This book covers all the cases and phenomenons a student and professional doctor might be up against in their whole life. Master this book and you will be of prime help in solving cases of diseases that are difficult to treat. Make a difference. Download Now.

The Authors

Lifespan Why We Age PDF

David A. Sinclair, Ph.D., A.O. is one of the world’s most famous and influential scientists. He is a tenured Professor at Harvard Medical School and TIME magazine named him “one of the 100 most influential people in the world” (2014) and among the “Top 50 People in Healthcare” (2018). His newsletter is at www.lifespanbook.com and you can follow him on Twitter @davidasinclair or IG at davidsinclairphd.

David is on the board of directors of the American Federation for Aging Research and has received more than thirty-five awards for his research and is an inventor on 40 patents. Dr. Sinclair has been featured on The Joe Rogan Experience, 60 Minutes, a Barbara Walters special, The Today Show, Good Morning America, The Wall Street Journal, The New York Times, Fortune, and Newsweek, The Rich Roll podcast, among others.

After thirty years of searching for truths about human biology, David is in a unique position. If you were to visit him in Boston, you’d most likely find him hanging out in his lab at Harvard Medical School, where he’s a professor in the Department of Genetics and CoDirector of the Paul F. Glenn Center for Biological Mechanisms of Aging Research. He also runs a sister lab at his alma mater, the University of New South Wales in Sydney. In his labs, teams of brilliant students and PhDs have both accelerated and reversed aging in model organisms and have been responsible for some of the most cited research in the field, published in some of the world’s top scientific journals. He is also a cofounder of the journal Aging, which provides space to other scientists to publish their research on one of the most challenging and exciting questions of our time. He’s also a cofounder of the Academy for Health and Lifespan Research, a group of the top twenty researchers in aging worldwide.

In trying to make practical use of his discoveries, he has helped start a number of biotechnology companies and sits as chair of the scientific boards of advisers of several others. These companies work with hundreds of leading academics in scientific areas ranging from the origin of life to genomics to pharmaceuticals. He is, of course, aware of his own lab’s discoveries years before they are made public, but through these associations, he is also aware of many other transformational discoveries ahead of time, sometimes a decade ahead.

Having received the equivalent of a knighthood in Australia and taken on the role of an ambassador (hence the AO at the end of his name), he’s been spending quite a bit of his time briefing political and business leaders around the world about the ways our understanding of aging is changing—and what that means for humanity going forward.

He’s applied many of his scientific findings to his own life, as have many of his family members, friends, and colleagues. The results— which, it should be noted, are completely anecdotal—are encouraging. He’s now 50, and he feels like a kid. His wife and kids will tell you he acts like one, too. The all live in Boston and enjoy hiking, kayaking, and traveling to unique places in the world together.

David and his wife Sandra are committed to turning key discoveries into medicines and technologies that help the world. He is involved in a variety of activities beyond being an academic including being a founder, equity owner, adviser, member of the board of directors, consultant, investor, collaborator with, and inventor on patents licensed to companies working to improve the human condition or national security. These include Vium; Jupiter Orphan Therapeutics; CohBar; Galileo Bioscience; Wellomics; EdenRoc Sciences and its affiliates Arc Bio, Dovetail Genomics, Claret Medical, Revere Biosciences, UpRNA, MetroBiotech, and Liberty Biosecurity; and Life Biosciences and its affiliates Selphagy Therapeutics, Senolytic Therapeutics, Spotlight Therapeutics, Immetas Therapeutics, Lua, Animal Biosciences, Iduna, Continuum Innovation, Prana (now Alterity); and Jumpstart Fertility. He is an inventor on over forty patents, most of which are licensed to industry or have been filed by companies, including a patent application filed by Mayo Clinic and Harvard Medical School and licensed to Elysium Health, of which any proceeds to him are donated to research. He gives lectures at conferences, museums, not-for-profit events, and occasionally at companies, and he sits on the boards of not-for-profit organizations, including the American Federation for Aging Research. He also serves as an adviser to the Lorraine Cross Award. For an updated list of activities, see https://genetics.med.harvard.edu/sinclair/.

Dimensions and Characteristics of Lifespan Why We Age PDF

  • Identification Number ‏ : ‎ B07N4C6LGR
  • Publisher ‏ : ‎ Atria Books; Illustrated edition (September 10, 2019)
  • Publication date ‏ : ‎ September 10, 2019
  • Language ‏ : ‎ English
  • File size ‏ : ‎ 22063 KB
  • Text-to-Speech ‏ : ‎ Enabled
  • Screen Reader ‏ : ‎ Supported
  • Enhanced typesetting ‏ : ‎ Enabled
  • X-Ray ‏ : ‎ Enabled
  • Word Wise ‏ : ‎ Enabled
  • Print length ‏ : ‎ 433 pages
  • Lending ‏ : ‎ Not Enabled
  • Book Name : Lifespan Why We Age PDF

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Top reviews

Kindle Customer “Dr. Sinclair has been doing the podcast rounds and you can learn a lot more from those podcasts about his research than you can from this book. The book itself is full of anecdotes and socio-political-economic idea;, it might be useful as an introduction for those flirting with the idea of life extension, but this book isn’t for those who are already interested in it. There’s one page in the “Conclusion” section where he mentions what he does which is a 1g NMN, 1g resveratrol, Vitamin D, K2, 83mg aspirin, avoid sugar, bread, pasta, skip one meal a day, get your blood tested, don’t smoke, avoid plastic, excessive UV exposure, X-Rays, CT scans, sleep in a cold bedroom, do cold exposure, do exercise.”

 

R. Cronise “As one of the pioneers in longevity research, David challenged status quo and demonstrated that nature’s longevity genes seemed to be conserved throughout biology. This is good news, because the changes that occur with aging seem to be correctable later in life. This isn’t another self-help book with meal plans and shopping lists. Instead, it will guide you through the real challenges and progress on our path to not just living longer, but importantly, living healthier.

Although this is plenty technical, it’s not an academic tome. Anyone, researcher or layman alike, will be able to follow the story thanks to the inclusion of so many personal accounts and reflections. After finishing, you will have a new perspective and hopefully realize that we have the ability right now to extend healthspan and the very real possibility of extending lifespan in the coming decade.

We met in 2009 and he encouraged me to write collaborative journal articles (metabolic winter hypothesis and oxidative priority) and now that work ultimately is the basis for our book, The Healthspan Solution, which focuses more on what we can achieve with diet. It’s been an honor working with him and having a man of his insight as a mentor and friend.”

Timothy D. Lundeen “. David makes three critical points:
* longer healthy lifespan improves all of our lives, not just personally, but for all of the people we love
* mechanisms to increase lifespan are part of our cells and often just need to be activated
* increasing healthy lifespan will not make the world overcrowded, but will benefit everyone by increasing productivity and overall well-being
All of these are well-supported and convincing, including touching and memorable personal experiences.

I do have one major issue, though. Our current medical system is focused on the bottom line, making money is more important than the best protocol. Look at Vioxx, for example, which killed thousands of people so that Merck could make more money. David has personal experiences with the system: his Mom almost died from poisoning by prescription medicine, and his daughter could have died from a serious Lyme infection that was not properly handled.

Yet David accepts that vaccination is a medical miracle, without doing any research on its risks and benefits. I hope he will take a serious look at all the issues:
* the extremely high rates of chronic illness in vaccinated vs non-vaccinated children, The Children’s Health Defense has a good series based on peer-reviewed research
* the connection between aluminum and autism, with artists having the highest levels. See Dr Chris Exley’s peer-reviewed work. Most vaccines have high levels of aluminum that has been shown to stay in the body and migrate to the brain
* the connection between vaccination-induced brain inflammation and brain injury, see vaccine papers dot org, which includes full-text copies of peer-reviewed research: “powerful scientific evidence has emerged indicating that vaccines cause brain injury such as autism, epilepsy, schizophrenia, depression, attention-deficit disorder and other mental illnesses. This scientific evidence has been largely ignored by the media, and by medical institutions that are supposedly guided by science.”
* the actual history of vaccination. Medical historians estimate that ALL of modern medicine, including vaccination and antibiotics, reduced childhood mortality by 4-6%. That is, 94-96% of the reduction was from improved sanitation and nutrition. For example, scarlet fever has been eradicated — without any vaccine. A good source is the book Dissolving Illusions.
* the actual contents of vaccines as analyzed by Corvelva, showing high levels of contamination
* the lack of liability for vaccines by the medical industry. Instead, a government fund compensates injuries, and has paid out over $4 billion. This does not motivate safer vaccines!”

Honest Reviewer “Although the book is split into three sections – the past, the present and the future – it reads as two halves: what is essentially scientific and what is decidedly ethical. When Dr Sinclair confines himself to his subject, it very difficult to put the book down. He discusses the advances in genomics, etc, that led him and others to studying ageing, before discussing current research and the notion that ageing is more a disease than a natural process. He includes some scientific detail, a few useful analogies and a good smattering of anecdotes to impress and educate the reader, which, despite some obvious padding, he undeniably does.
I think a typical scientist would and should stop right there; for science does not concern itself with morality but with pure knowledge whether constructive or destructive. Nonetheless, Dr Sinclair goes on to debate the real and political consequences of people living, if not forever, certainly much longer than they do now. To me, this is where the book rapidly goes down hill. Dr Sinclair knows there will be serious repercussions: an increase in population; a greater demand for resources; more pollution; more carbon emissions; etc, etc. He says that alongside the big increase in population in the 1800’s was a huge increase in the standard of sanitation and health as though it were causative – more people lead to more benefits. He thinks that GMO and foods modified by other technologies will provide the solution to feeding the ever-increasing numbers of mouths and gets irritated when some people have the temerity to question their safety. Also, because he would be content to work doing his interesting research in his lab for the next 50 years, it does not mean a miner would like to spend another 50 digging coal.
Despite Dr Sinclair’s faith in the ingenuity of man, there are times when i sense he is trying to convince himself of his utopian vision rather than the reader. Living to infinity is not the be all and end all; living a healthy life is more important, whether one lives to 70 or 90.
At some point I will re-read the first half of the book – which I enjoyed – but not the second. I must be only part Luddite.”
Source : Amazon

Lifespan Why We Age PDF

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