Harrison’s Principles of Internal Medicine 21st Edition PDF 2022 Download


In this blog post on allthingsmedicine we will share the pdf file for the latest edition in the harrison’s internal medicine books for medical students and physicians. The book is uploaded to the cloud server and is not hosted on our blog. Harrison’s Principles of internal medicine 21st edition pdf is a worldwide recognized book among medical students for preparation during their residency when they aspire to be general physicians. Shown below are some of the features that you should read before downloading the book.


Harrison’s principles of internal medicine has always been the guiding light for students since years and this latest edition adds more revamped features described below.

Harrison’s Principles of Internal Medicine is the world’s most trusted clinical medicine text―and a superb resource for learning the art and science of clinical reasoning. Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine provides the informational foundation you need for the best patient care possible. This new edition is fully updated with timely new chapters and essential updates across the spectrum of internal medicine.

Written and edited by the world’s top experts in their respective fields, this landmark guide provides comprehensive, accurate, and essential coverage of the pathogenesis, diagnosis, and treatment of disease.

Harrison’s is world-renowned as the most authoritative source for: 

• Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases
• The physiologic and etiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow
• Updated clinical trial results and recommended guidelines
• Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings
• Coverage of both therapeutic approaches and specific treatment regimens
• Practical clinical decision trees and algorithms
• Organ/system-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, and general and specific approaches to therapy

Current coverage of the diagnosis and treatment of diseases

from COVID to dementia to sepsis to multiple sclerosis to lung cancer

Updated content

that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries

More than 1000 clinical, pathological, and radiographic

photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes

Numerous atlases

featuring curated collections of important visual aspects of diagnosis and management

Updated and time-saving curation

and synthesis of established and new medical literature and studies

Clinically relevant coverage

of disease mechanics and pathophysiology, and related therapeutic mechanisms

Book Details

Harrisons-principles-of-internal-medicine-21st-edition pdf

Publisher ‏ : ‎ McGraw Hill / Medical; 21st edition (March 28, 2022)
Language ‏ : ‎ English
Hardcover ‏ : ‎ 4384 pages
ISBN-10 ‏ : ‎ 1264268505
ISBN-13 ‏ : ‎ 978-1264268504
Item Weight ‏ : ‎ 14.26 pounds
Dimensions ‏ : ‎ 8.9 x 4.7 x 11.7 inches
Best Sellers Rank: #17,934 in Books (See Top 100 in Books)
#1 in Diseases
#2 in Internal Medicine (Books)
#76 in Medical Diseases (Books)

Units and Chapters of Harrison’s Principles of Internal Medicine 21st Edition PDF

Part 1: The Profession of Medicine
Chapter 1: The Practice of Medicine
Chapter 2: Promoting Good Health
Chapter 3: Vaccine Opposition and Hesitancy
Chapter 4: Decision-Making in Clinical Medicine
Chapter 5: Precision Medicine and Clinical Care
Chapter 6: Screening and Prevention of Disease
Chapter 7: Global Diversity of Health System Financing and Delivery
Chapter 8: The Safety and Quality of Health Care
Chapter 9: Diagnosis: Reducing Errors and Improving Quality
Chapter 10: Racial and Ethnic Disparities in Health Care
Chapter 11: Ethical Issues in Clinical Medicine
Chapter 12: Palliative and End-of-Life Care
Part 2: Cardinal Manifestations and Presentation of Diseases
Section 1: Pain
Chapter 13: Pain: Pathophysiology and Management
Chapter 14: Chest Discomfort
Chapter 15: Abdominal Pain
Chapter 16: Headache
Chapter 17: Back and Neck Pain
Section 2: Alterations in Body Temperature
Chapter 18: Fever
Chapter 19: Fever and Rash
Chapter 20: Fever of Unknown Origin
Section 3: Nervous System Dysfunction
Chapter 21: Syncope
Updated! Chapter 22: Dizziness and Vertigo
Chapter 23: Fatigue
Chapter 24: Neurologic Causes of Weakness and Paralysis
Chapter 25: Numbness, Tingling, and Sensory Loss
Chapter 26: Gait Disorders, Imbalance, and Falls
Chapter 27: Confusion and Delirium
Chapter 28: Coma
Chapter 29: Dementia
Chapter 30: Aphasia, Memory Loss, and Other Cognitive Disorders
Chapter 31: Sleep Disorders
Section 4: Disorders of Eyes, Ears, Nose, and Throat
Chapter 32: Disorders of the Eye
Chapter 33: Disorders of Smell and Taste
Chapter 34: Disorders of Hearing
Chapter 35: Upper Respiratory Symptoms, Including Earache, Sinus Symptoms, and Sore Throat
Chapter 36: Oral Manifestations of Disease
Section 5: Alterations in Circulatory and Respiratory Functions
Chapter 37: Dyspnea
Chapter 38: Cough
Chapter 39: Hemoptysis
Chapter 40: Hypoxia and Cyanosis
Chapter 41: Edema
Chapter 42: Approach to the Patient with a Heart Murmur
Chapter 43: Palpitations
Section 6: Alterations in Gastrointestinal Function
Chapter 44: Dysphagia
Chapter 45: Nausea, Vomiting, and Indigestion
Chapter 46: Diarrhea and Constipation
Chapter 47: Unintentional Weight Loss
Chapter 48: Gastrointestinal Bleeding
Chapter 49: Jaundice
Chapter 50: Abdominal Swelling and Ascites
Section 7: Alterations in Renal and Urinary Tract Function
Chapter 51: Interstitial Cystitis/Bladder Pain Syndrome
Chapter 52: Azotemia and Urinary Abnormalities
Chapter 53: Fluid and Electrolyte Disturbances
Chapter 54: Hypercalcemia and Hypocalcemia
Chapter 55: Acidosis and Alkalosis
Section 8: Alterations in the Skin
Chapter 56: Approach to the Patient with a Skin Disorder
Chapter 57: Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
Chapter 58: Skin Manifestations of Internal Disease
Chapter 59: Immunologically Mediated Skin Diseases
Chapter 60: Cutaneous Drug Reactions
Chapter 61: Photosensitivity and Other Reactions to Sunlight
Section 9: Hematologic Alterations
Chapter 62: Interpreting Peripheral Blood Smears
Updated! Chapter 63: Anemia and Polycythemia
Chapter 64: Disorders of Granulocytes and Monocytes
Chapter 65: Bleeding and Thrombosis
Chapter 66: Enlargement of Lymph Nodes and Spleen
Part 3: Pharmacology
Chapter 67: Principles of Clinical Pharmacology
Chapter 68: Pharmacogenomics
Part 4: Oncology and Hematology
Section 1: Neoplastic Disorders
Chapter 69: Approach to the Patient with Cancer
Chapter 70: Prevention and Early Detection of Cancer
Chapter 71: Cancer Genetics
Chapter 72: Cancer Cell Biology
Chapter 73: Principles of Cancer Treatment
Chapter 74: Infections in Patients with Cancer
Chapter 75: Oncologic Emergencies
Chapter 76: Cancer of the Skin
Chapter 77: Head and Neck Cancer
Chapter 78: Neoplasms of the Lung
Chapter 79: Breast Cancer
Chapter 80: Upper Gastrointestinal Tract Cancers
Chapter 81: Lower Gastrointestinal Cancers
Chapter 82: Tumors of the Liver and Biliary Tree
Chapter 83: Pancreatic Cancer
Chapter 84: Gastrointestinal Neuroendocrine Tumors
Chapter 85: Renal Cell Carcinoma
Chapter 86: Cancer of the Bladder and Urinary Tract
Chapter 87: Benign and Malignant Diseases of the Prostate
Chapter 88: Testicular Cancer
Chapter 89: Gynecologic Malignancies
Chapter 90: Primary and Metastatic Tumors of the Nervous System
Chapter 91: Soft Tissue and Bone Sarcomas and Bone Metastases
Chapter 92: Carcinoma of Unknown Primary
Chapter 93: Paraneoplastic Syndromes: Endocrinologic/Hematologic
Chapter 94: Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis
Chapter 95: Cancer Survivorship and the Long-Term Impact of Cancer and Its Treatment
Section 2: Hematopoietic Disorders
Chapter 96: Hematopoietic Stem Cells
Chapter 97: Iron Deficiency and Other Hypoproliferative Anemias
Chapter 98: Disorders of Hemoglobin
Chapter 99: Megaloblastic Anemias
Chapter 100: Hemolytic Anemias
Chapter 101: Anemia Due to Acute Blood Loss
Chapter 102: Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia
Chapter 103: Polycythemia Vera and Other Myeloproliferative Neoplasms
Chapter 104: Acute Myeloid Leukemia
Chapter 105: Chronic Myeloid Leukemia
Chapter 106: Acute Lymphoid Leukemia
Chapter 107: Chronic Lymphocytic Leukemia
Chapter 108: Non-Hodgkin’s Lymphoma
Chapter 109: Hodgkin’s Lymphoma
Chapter 110: Less Common Lymphoid and Myeloid Malignancies
Chapter 111: Plasma Cell Disorders
Chapter 112: Amyloidosis
Chapter 114: Hematopoietic Cell Transplantation
Chapter 113: Transfusion Therapy and Biology
Section 3: Disorders of Hemostasis
Chapter 115: Disorders of Platelets and Vessel Wall
Chapter 116: Coagulation Disorders
Chapter 117: Arterial and Venous Thrombosis
Chapter 118: Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
Part 5: Infectious Diseases
Section 1: Basic Considerations in Infectious Diseases
Updated! Chapter 119: Approach to the Patient with an Infectious Disease
Chapter 120: Molecular Mechanisms of Microbial Pathogenesis
Chapter 121: Microbial Genomics and Infectious Disease
Chapter 122: Approach to the Acutely Ill Infected Febrile Patient
Chapter 123: Immunization Principles and Vaccine Use
Chapter 124: Health Recommendations for International Travel
Chapter 125: Climate Change and Infectious Disease
Section 2: Clinical Syndromes: Community-Acquired Infections
Updated! Chapter 126: Pneumonia
Updated! Chapter 127: Lung Abscess
Updated! Chapter 128: Infective Endocarditis
Updated! Chapter 129: Infections of the Skin, Muscles, and Soft Tissues
Updated! Chapter 130: Infectious Arthritis
Updated! Chapter 131: Osteomyelitis
Updated! Chapter 132: Intraabdominal Infections and Abscesses
Updated! Chapter 133: Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
Updated! Chapter 134: Clostridioides difficile Infection, Including Pseudomembranous Colitis
Updated! Chapter 135: Urinary Tract Infections, Pyelonephritis, and Prostatitis
Updated! Chapter 136: Sexually Transmitted Infections: Overview and Clinical Approach
Updated! Chapter 137: Encephalitis
Updated! Chapter 138: Acute Meningitis
Updated! Chapter 139: Chronic and Recurrent Meningitis
Updated! Chapter 140: Brain Abscess and Empyema
Updated! Chapter 141: Infectious Complications of Bites
Section 3: Clinical Syndromes: Health Care-Associated Infections
Chapter 142: Infections Acquired in Health Care Facilities
Chapter 143: Infections in Transplant Recipients
Section 4: Therapy for Bacterial Diseases
Chapter 144: Treatment and Prophylaxis of Bacterial Infections
Chapter 145: Bacterial Resistance to Antimicrobial Agents
Section 5: Diseases Caused by Gram-Positive Bacteria
Updated! Chapter 146: Pneumococcal Infections
Updated! Chapter 147: Staphylococcal Infections
Updated! Chapter 148: Streptococcal Infections
Updated! Chapter 149: Enterococcal Infections
Updated! Chapter 150: Diphtheria and Other Corynebacterial Infections
Updated! Chapter 151: Listeria monocytogenes Infections
Updated! Chapter 152: Tetanus
Updated! Chapter 153: Botulism
Updated! Chapter 154: Gas Gangrene and Other Clostridial Infections
Section 6: Diseases Caused by Gram-Negative Bacteria
Updated! Chapter 155: Meningococcal Infections
Updated! Chapter 156: Gonococcal Infections
Updated! Chapter 157: Haemophilus and Moraxella Infections
Updated! Chapter 158: Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
Updated! Chapter 159: Legionella Infections
Updated! Chapter 160: Pertussis and Other Bordetella Infections
Updated! Chapter 161: Diseases Caused by Gram-Negative Enteric Bacilli
Updated! Chapter 162: Acinetobacter Infections
Updated! Chapter 163: Helicobacter pylori Infections
Updated! Chapter 164: Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species
Updated! Chapter 165: Salmonellosis
Chapter 166: Shigellosis
Updated! Chapter 167: Infections Due to Campylobacter and Related Organisms
Updated! Chapter 168: Cholera and Other Vibrioses
Updated! Chapter 169: Brucellosis
Updated! Chapter 170: Tularemia
Updated! Chapter 171: Plague and Other Yersinia Infections
Updated! Chapter 172: Bartonella Infections, Including Cat-Scratch Disease
Updated! Chapter 173: Donovanosis
Section 7: Miscellaneous Bacterial Infections
Updated! Chapter 174: Nocardiosis
Updated! Chapter 175: Actinomycosis
Updated! Chapter 176: Whipple’s Disease
Updated! Chapter 177: Infections Due to Mixed Anaerobic Organisms
Section 8: Mycobacterial Diseases
Updated! Chapter 178: Tuberculosis
Updated! Chapter 179: Leprosy
Updated! Chapter 180: Nontuberculous Mycobacterial Infections
Chapter 181: Antimycobacterial Agents
Section 9: Spirochetal Diseases
Updated! Chapter 182: Syphilis
Updated! Chapter 183: Endemic Treponematoses
Chapter 184: Leptospirosis
Updated! Chapter 185: Relapsing Fever and Borrelia miyamotoi Disease
Updated! Chapter 186: Lyme Borreliosis
Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
Updated! Chapter 187: Rickettsial Diseases
Updated! Chapter 188: Infections Due to Mycoplasmas
Updated! Chapter 189: Chlamydial Infections
Section 11: Viral Diseases: General Considerations
Chapter 190: Principles of Medical Virology
Chapter 191: Antiviral Chemotherapy, Excluding Antiretroviral Drugs
Section 12: Infections Due to DNA Viruses
Updated! Chapter 192: Herpes Simplex Virus Infections
Updated! Chapter 193: Varicella-Zoster Virus Infections
Updated! Chapter 194: Epstein-Barr Virus Infections, Including Infectious Mononucleosis
Updated! Chapter 195: Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
Chapter 196: Molluscum Contagiosum, Mpox, and Other Poxvirus Infections
Updated! Chapter 197: Parvovirus Infections
Updated! Chapter 198: Human Papillomavirus Infections
Section 13: Infections Due to DNA and RNA Respiratory Viruses
Updated! Chapter 199: Common Viral Respiratory Infections, Including COVID-19
Updated! Chapter 200: Influenza
Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
Updated! Chapter 201: The Human Retroviruses
Updated! Chapter 202: Human Immunodeficiency Virus Disease: AIDS and Related Disorders
Section 15: Infections Due to RNA Viruses
Updated! Chapter 203: Viral Gastroenteritis
Updated! Chapter 204: Enterovirus, Parechovirus, and Reovirus Infections
Updated! Chapter 205: Measles (Rubeola)
Updated! Chapter 206: Rubella (German Measles)
Updated! Chapter 207: Mumps
Updated! Chapter 208: Rabies and Other Rhabdovirus Infections
Chapter 209: Arthropod-Borne and Rodent-Borne Virus Infections
Updated! Chapter 210: Ebolavirus and Marburgvirus Infections
Section 16: Fungal Infections
Chapter 211: Pathogenesis, Diagnosis, and Treatment of Fungal Infections
Updated! Chapter 212: Histoplasmosis
Updated! Chapter 213: Coccidioidomycosis
Updated! Chapter 214: Blastomycosis
Updated! Chapter 215: Cryptococcosis
Updated! Chapter 216: Candidiasis
Updated! Chapter 217: Aspergillosis
Updated! Chapter 218: Mucormycosis
Chapter 219: Less Common Systemic Mycoses and Superficial Mycoses
Updated! Chapter 220: Pneumocystis Infections
Section 17: Protozoal and Helminthic Infections: General Considerations
Updated! Chapter 221: Introduction to Parasitic Infections
Chapter 222: Agents Used to Treat Parasitic Infections
Section 18: Protozoal Infections
Updated! Chapter 223: Amebiasis and Infection with Free-Living Amebae
Updated! Chapter 224: Malaria
Updated! Chapter 225: Babesiosis
Updated! Chapter 226: Leishmaniasis
Updated! Chapter 227: Chagas Disease and African Trypanosomiasis
Updated! Chapter 228: Toxoplasma Infections
Updated! Chapter 229: Protozoal Intestinal Infections and Trichomoniasis
Section 19: Helminthic Infections
Chapter 230: Introduction to Helminthic Infections
Updated! Chapter 231: Trichinellosis and Other Tissue Nematode Infections
Updated! Chapter 232: Intestinal Nematode Infections
Updated! Chapter 233: Filarial and Related Infections
Updated! Chapter 234: Schistosomiasis and Other Trematode Infections
Updated! Chapter 235: Cestode Infections
Part 6: Disorders of the Cardiovascular System
Section 1: Introduction to Cardiovascular Disorders
Chapter 236: Approach to the Patient with Possible Cardiovascular Disease
Chapter 237: Basic Biology of the Cardiovascular System
Chapter 238: Epidemiology of Cardiovascular Disease
Section 2: Diagnosis of Cardiovascular Disorders
Chapter 239: Physical Examination of the Cardiovascular System
Updated! Chapter 241: Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging
Chapter 240: Electrocardiography
Chapter 242: Diagnostic Cardiac Catheterization and Coronary Angiography
Section 3: Disorders of Rhythm
Updated! Chapter 243: Principles of Clinical Cardiac Electrophysiology
Updated! Chapter 244: The Bradyarrhythmias: Disorders of the Sinoatrial Node
Updated! Chapter 245: The Bradyarrhythmias: Disorders of the Atrioventricular Node
Chapter 246: Approach to Supraventricular Tachyarrhythmias
Chapter 247: Physiologic and Nonphysiologic Sinus Tachycardia
Chapter 248: Focal Atrial Tachycardia
Updated! Chapter 249: Paroxysmal Supraventricular Tachycardias
Chapter 250: Common Atrial Flutter and Macroreentrant and Multifocal Atrial Tachycardias
Updated! Chapter 251: Atrial Fibrillation
Chapter 252: Approach to Ventricular Arrhythmias
Chapter 253: Premature Ventricular Contractions, Nonsustained Ventricular Tachycardia, and Accelerated Idioventricular Rhythm
Chapter 254: Sustained Ventricular Tachycardia
Chapter 255: Polymorphic Ventricular Tachycardia and Ventricular Fibrillation
Chapter 256: Electrical Storm and Incessant Ventricular Tachycardia
Section 4: Disorders of the Heart, Muscles, Valves, and Pericardium
Chapter 257: Heart Failure: Pathophysiology and Diagnosis
Chapter 258: Heart Failure: Management
Updated! Chapter 259: Cardiomyopathy and Myocarditis
Chapter 260: Cardiac Transplantation and Prolonged Assisted Circulation
Updated! Chapter 261: Aortic Stenosis
Updated! Chapter 262: Aortic Regurgitation
Updated! Chapter 263: Mitral Stenosis
Updated! Chapter 264: Mitral Regurgitation
Updated! Chapter 265: Mitral Valve Prolapse
Updated! Chapter 266: Tricuspid Valve Disease
Updated! Chapter 267: Pulmonic Valve Disease
Updated! Chapter 268: Multiple and Mixed Valvular Heart Disease
Chapter 269: Congenital Heart Disease in the Adult
Updated! Chapter 270: Pericardial Disease
Updated! Chapter 271: Atrial Myxoma and Other Cardiac Tumors
Updated! Chapter 272: Cardiac Trauma
Section 5: Coronary and Peripheral Vascular Disease
Updated! Chapter 273: Ischemic Heart Disease
Updated! Chapter 274: Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)
Updated! Chapter 275: ST-Segment Elevation Myocardial Infarction
Chapter 276: Percutaneous Coronary Interventions and Other Interventional Procedures
Updated! Chapter 277: Hypertension
Updated! Chapter 278: Renovascular Disease
Updated! Chapter 279: Deep-Venous Thrombosis and Pulmonary Thromboembolism
Updated! Chapter 280: Diseases of the Aorta
Updated! Chapter 281: Arterial Diseases of the Extremities
Updated! Chapter 282: Chronic Venous Disease and Lymphedema
Chapter 283: Pulmonary Hypertension
Part 7: Disorders of the Respiratory System
Section 1: Diagnosis of Respiratory Disorders
Chapter 284: Approach to the Patient with Disease of the Respiratory System
Chapter 285: Disturbances of Respiratory Function
Chapter 286: Diagnostic Procedures in Respiratory Disease
Section 2: Diseases of the Respiratory System
Updated! Chapter 287: Asthma
Updated! Chapter 288: Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
Chapter 289: Occupational and Environmental Lung Disease
Updated! Chapter 290: Bronchiectasis
Updated! Chapter 291: Cystic Fibrosis
Updated! Chapter 292: Chronic Obstructive Pulmonary Disease
Chapter 293: Interstitial Lung Disease
Chapter 294: Disorders of the Pleura
Chapter 295: Disorders of the Mediastinum
Updated! Chapter 296: Disorders of Ventilation
Updated! Chapter 297: Sleep Apnea
Chapter 298: Lung Transplantation
Chapter 299: Interventional Pulmonary Medicine
Part 8: Critical Care Medicine
Section 1: Respiratory Critical Care
Chapter 300: Approach to the Patient with Critical Illness
Updated! Chapter 301: Acute Respiratory Distress Syndrome
Chapter 302: Mechanical Ventilatory Support
Section 2: Shock and Cardiac Arrest
Chapter 303: Approach to the Patient with Shock
Updated! Chapter 304: Sepsis and Septic Shock
Updated! Chapter 305: Cardiogenic Shock and Pulmonary Edema
Chapter 306: Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death
Section 3: Neurologic Critical Care
Updated! Chapter 307: Nervous System Disorders in Critical Care
Part 9: Disorders of the Kidney and Urinary Tract
Chapter 308: Approach to the Patient with Renal Disease or Urinary Tract Disease
Chapter 309: Cell Biology and Physiology of the Kidney
Chapter 310: Acute Kidney Injury
Updated! Chapter 311: Chronic Kidney Disease
Chapter 312: Dialysis in the Treatment of Kidney Failure
Chapter 313: Transplantation in the Treatment of Renal Failure
Updated! Chapter 314: Glomerular Diseases
Updated! Chapter 315: Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development
Updated! Chapter 316: Tubulointerstitial Diseases of the Kidney
Updated! Chapter 317: Vascular Injury to the Kidney
Updated! Chapter 318: Nephrolithiasis
Updated! Chapter 319: Urinary Tract Obstruction
Updated! Chapter 320: Interventional Nephrology
Part 10: Disorders of the Gastrointestinal System
Section 1: Disorders of the Alimentary Tract
Updated! Chapter 321: Approach to the Patient with Gastrointestinal Disease
Chapter 322: Gastrointestinal Endoscopy
Updated! Chapter 323: Diseases of the Esophagus
Updated! Chapter 324: Peptic Ulcer Disease and Related Disorders
Updated! Chapter 325: Disorders of Absorption
Updated! Chapter 326: Inflammatory Bowel Disease
Updated! Chapter 327: Irritable Bowel Syndrome
Updated! Chapter 328: Diverticular Disease and Common Anorectal Disorders
Chapter 329: Mesenteric Vascular Insufficiency
Updated! Chapter 330: Acute Intestinal Obstruction
Updated! Chapter 331: Acute Appendicitis and Peritonitis
Section 2: Nutrition
Chapter 332: Nutrient Requirements and Dietary Assessment
Updated! Chapter 333: Vitamin and Trace Mineral Deficiency and Excess
Chapter 334: Malnutrition and Nutritional Assessment
Updated! Chapter 335: Enteral and Parenteral Nutrition
Section 3: Liver and Biliary Tract Disease
Chapter 336: Approach to the Patient with Liver Disease
Chapter 337: Evaluation of Liver Function
Chapter 338: The Hyperbilirubinemias
Updated! Chapter 339: Acute Viral Hepatitis
Updated! Chapter 340: Toxic and Drug-Induced Hepatitis
Updated! Chapter 341: Chronic Hepatitis
Updated! Chapter 342: Alcohol-Associated Liver Disease
Chapter 343: Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis
Updated! Chapter 344: Cirrhosis and Its Complications
Chapter 345: Liver Transplantation
Updated! Chapter 346: Diseases of the Gallbladder and Bile Ducts
Section 4: Disorders of the Pancreas
Chapter 347: Approach to the Patient with Pancreatic Disease
Updated! Chapter 348: Acute and Chronic Pancreatitis
Part 11: Immune-Mediated, Inflammatory, and Rheumatologic Disorders
Section 1: The Immune System in Health and Disease
Chapter 349: Introduction to the Immune System
Chapter 350: Mechanisms of Regulation and Dysregulation of the Immune System
Chapter 351: Primary Immune Deficiency Diseases
Section 2: Disorders of Immune-Mediated Injury
Updated! Chapter 352: Urticaria, Angioedema, and Allergic Rhinitis
Chapter 353: Anaphylaxis
Updated! Chapter 354: Mastocytosis
Updated! Chapter 355: Autoimmunity and Autoimmune Diseases
Chapter 356: Systemic Lupus Erythematosus
Updated! Chapter 357: Antiphospholipid Syndrome
Updated! Chapter 358: Rheumatoid Arthritis
Updated! Chapter 359: Acute Rheumatic Fever
Updated! Chapter 360: Systemic Sclerosis (Scleroderma) and Related Disorders
Updated! Chapter 361: Sjögren’s Syndrome
Updated! Chapter 362: Spondyloarthritis
Updated! Chapter 363: The Vasculitis Syndromes
Updated! Chapter 364: Behçet Syndrome
Chapter 365: Inflammatory Myopathies
Updated! Chapter 366: Relapsing Polychondritis
Updated! Chapter 367: Sarcoidosis
Chapter 368: IgG4-Related Disease
Updated! Chapter 369: Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases
Section 3: Disorders of the Joints and Adjacent Tissues
Chapter 370: Approach to Articular and Musculoskeletal Disorders
Updated! Chapter 371: Osteoarthritis
Updated! Chapter 372: Gout and Other Crystal-Associated Arthropathies
Updated! Chapter 373: Fibromyalgia
Updated! Chapter 374: Arthritis Associated with Systemic Disease, and Other Arthritides
Chapter 375: Periarticular Disorders of the Extremities
Part 12: Endocrinology and Metabolism
Section 1: Endocrinology
Chapter 376: Approach to the Patient with Endocrine Disorders
Chapter 377: Mechanisms of Hormone Action
Chapter 378: Physiology of Anterior Pituitary Hormones
Updated! Chapter 379: Hypopituitarism
Updated! Chapter 380: Pituitary Tumor Syndromes
Updated! Chapter 381: Disorders of the Neurohypophysis
Chapter 382: Thyroid Gland Physiology and Testing
Updated! Chapter 383: Hypothyroidism
Updated! Chapter 384: Hyperthyroidism and Other Causes of Thyrotoxicosis
Updated! Chapter 385: Thyroid Nodular Disease and Thyroid Cancer
Updated! Chapter 386: Disorders of the Adrenal Cortex
Updated! Chapter 387: Pheochromocytoma
Updated! Chapter 388: Multiple Endocrine Neoplasia Syndromes
Updated! Chapter 389: Autoimmune Polyendocrine Syndromes
Section 2: Sex- and Gender-Based Medicine
Updated! Chapter 390: Sex Development
Updated! Chapter 391: Disorders of the Testes and Male Reproductive System
Chapter 392: Disorders of the Female Reproductive System
Updated! Chapter 393: Menstrual Disorders and Pelvic Pain
Updated! Chapter 394: Hirsutism
Updated! Chapter 395: Menopause and Postmenopausal Hormone Therapy
Chapter 396: Infertility and Contraception
Updated! Chapter 397: Sexual Dysfunction
Chapter 398: Women’s Health
Updated! Chapter 399: Men’s Health
Chapter 400: Lesbian, Gay, Bisexual, and Transgender (LGBT) Health
Section 3: Obesity, Diabetes Mellitus, and Metabolic Syndrome
Chapter 401: Pathobiology of Obesity
Updated! Chapter 402: Evaluation and Management of Obesity
Updated! Chapter 403: Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology
Updated! Chapter 404: Diabetes Mellitus: Management and Therapies
Updated! Chapter 405: Diabetes Mellitus: Complications
Updated! Chapter 406: Hypoglycemia
Updated! Chapter 407: Disorders of Lipoprotein Metabolism
Updated! Chapter 408: The Metabolic Syndrome
Section 4: Disorders of Bone and Mineral Metabolism
Updated! Chapter 409: Bone and Mineral Metabolism in Health and Disease
Updated! Chapter 410: Disorders of the Parathyroid Gland and Calcium Homeostasis
Updated! Chapter 411: Osteoporosis
Updated! Chapter 412: Paget’s Disease and Other Dysplasias of Bone
Section 5: Disorders of Intermediary Metabolism
Updated! Chapter 413: Heritable Disorders of Connective Tissue
Updated! Chapter 414: Hemochromatosis
Updated! Chapter 415: Wilson’s Disease
Updated! Chapter 416: The Porphyrias
Updated! Chapter 417: Disorders of Purine and Pyrimidine Metabolism
Chapter 418: Lysosomal Storage Diseases
Chapter 419: Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism
Updated! Chapter 420: Inherited Disorders of Amino Acid Metabolism in Adults
Chapter 421: Inherited Defects of Membrane Transport
Part 13: Neurologic Disorders
Section 1: Diagnosis of Neurologic Disorders
Chapter 422: Approach to the Patient with Neurologic Disease
Chapter 423: Neuroimaging in Neurologic Disorders
Chapter 424: Pathobiology of Neurologic Diseases
Section 2: Diseases of the Central Nervous System
Updated! Chapter 425: Seizures and Epilepsy
Updated! Chapter 426: Introduction to Cerebrovascular Diseases
Updated! Chapter 427: Ischemic Stroke
Updated! Chapter 428: Intracranial Hemorrhage
Updated! Chapter 429: Subarachnoid Hemorrhage
Updated! Chapter 430: Migraine and Other Primary Headache Disorders
Updated! Chapter 431: Alzheimer’s Disease
Chapter 432: Frontotemporal Dementia
Updated! Chapter 433: Vascular Dementia
Updated! Chapter 434: Dementia with Lewy Bodies
Updated! Chapter 435: Parkinson’s Disease
Updated! Chapter 436: Tremor, Chorea, and Other Movement Disorders
Updated! Chapter 437: Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
Chapter 438: Prion Diseases
Updated! Chapter 439: Ataxic Disorders
Updated! Chapter 440: Disorders of the Autonomic Nervous System
Updated! Chapter 441: Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders
Updated! Chapter 442: Diseases of the Spinal Cord
Chapter 443: Concussion and Other Traumatic Brain Injuries
Chapter 444: Multiple Sclerosis
Updated! Chapter 445: Neuromyelitis Optica
Section 3: Nerve and Muscle Disorders
Chapter 446: Peripheral Neuropathy
Updated! Chapter 447: Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies
Updated! Chapter 448: Myasthenia Gravis and Other Diseases of the Neuromuscular Junction
Updated! Chapter 449: Muscular Dystrophies and Other Muscle Diseases
Section 4: Chronic Fatigue Syndrome
Updated! Chapter 450: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Section 5: Psychiatric and Addiction Disorders
Chapter 451: Biology of Psychiatric Disorders
Updated! Chapter 452: Psychiatric Disorders
Updated! Chapter 453: Alcohol and Alcohol Use Disorders
Chapter 454: Nicotine Addiction
Chapter 455: Marijuana and Marijuana Use Disorders
Updated! Chapter 456: Opioid-Related Disorders
Updated! Chapter 457: Cocaine, Other Psychostimulants, and Hallucinogens
Part 14: Poisoning, Drug Overdose, and Envenomation
Chapter 458: Heavy Metal Poisoning
Updated! Chapter 459: Poisoning and Drug Overdose
Updated! Chapter 460: Disorders Caused by Venomous Snakebites and Marine Animal Exposures
Updated! Chapter 461: Ectoparasite Infestations and Arthropod Injuries
Part 15: Disorders Associated with Environmental Exposures
Chapter 462: Altitude Illness
Updated! Chapter 463: Hyperbaric and Diving Medicine
Updated! Chapter 464: Hypothermia and Peripheral Cold Injuries
Chapter 465: Heat-Related Illnesses
Part 16: Genes, the Environment, and Disease
Updated! Chapter 466: Principles of Human Genetics
Chapter 467: The Practice of Genetics in Clinical Medicine
Chapter 468: Mitochondrial DNA and Heritable Traits and Diseases
Updated! Chapter 469: Telomere Disease
Chapter 470: Gene- and Cell-Based Therapy in Clinical Medicine
Chapter 471: The Human Microbiome
Part 17: Global Medicine
Chapter 472: Global Issues in Medicine
Chapter 473: Emerging and Reemerging Infectious Diseases
Chapter 474: Primary Care and Global Health
Chapter 475: Health Effects of Climate Change
Part 18: Aging
Chapter 476: Biology of Aging
Chapter 477: Caring for the Geriatric Patient
Part 19: Consultative Medicine
Chapter 478: Approach to Medical Consultation
Updated! Chapter 479: Medical Disorders During Pregnancy
Chapter 480: Medical Evaluation of the Surgical Patient
Part 20: Frontiers
Chapter 481: Behavioral Economics and Health
Chapter 482: Complementary and Integrative Therapies and Practices
Chapter 483: The Role of Epigenetics in Disease and Treatment
Chapter 484: Applications of Stem Cell Biology in Clinical Medicine
Chapter 485: The Role of Circadian Biology in Health and Disease
Chapter 486: Network Medicine: Systems Biology in Health and Disease
Chapter 487: Emerging Neurotherapeutic Technologies
Chapter 488: Machine Learning and Augmented Intelligence in Clinical Medicine
Chapter 489: Metabolomics
Chapter 490: Circulating Nucleic Acids as Liquid Biopsies and Noninvasive Disease Biomarkers
Chapter 491: Protein Folding Disorders
Chapter 492: Novel Approaches to Diseases of Unknown Etiology
Part 21: Video Collection
Chapter V1: Video Library of Gait Disorders
Chapter V2: Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral Disorders
Chapter V3: Video Library of Neuro-Ophthalmology
Chapter V4: Examination of the Comatose Patient
Chapter V5: Video Atlas of Gastrointestinal Endoscopic Lesions
Chapter V6: The Neurologic Screening Exam
Chapter V7: Video Atlas of the Detailed Neurologic Examination
Part 22: Supplementary Topics
Chapter S1: Fluid and Electrolyte Imbalances and Acid-Base Disturbances: Case Examples
Chapter S2: Cerebrospinal Fluid Disturbances: Case Examples
Updated! Chapter S3: Microbial Bioterrorism
Updated! Chapter S4: Chemical Terrorism
Updated! Chapter S5: Radiation Terrorism
Chapter S6: Infections in War Veterans
Chapter S7: Health Care for Military Veterans
Chapter S8: Primary Immunodeficiencies Associated with (or Secondary to) Other Diseases
Chapter S9: Technique of Lumbar Puncture
Chapter S10: The Clinical Laboratory in Modern Health Care
Chapter S11: Laboratory Diagnosis of Infectious Diseases
Chapter S12: Laboratory Diagnosis of Parasitic Infections
Part 23: Atlases
Chapter A1: Atlas of Rashes Associated with Fever
Chapter A2: Atlas of Blood Smears of Malaria and Babesiosis
Chapter A3: Atlas of Oral Manifestations of Disease
Chapter A4: Atlas of Urinary Sediments and Renal Biopsies
Chapter A5: Atlas of Skin Manifestations of Internal Disease
Chapter A6: Atlas of Hematology
Chapter A7: Atlas of Electrocardiography
Chapter A8: Atlas of Cardiac Arrhythmias
Chapter A9: Atlas of Noninvasive Imaging
Chapter A10: Atlas of Atherosclerosis
Chapter A11: Atlas of Percutaneous Revascularization and Adult Structural Heart Interventions
Chapter A12: Atlas of Chest Imaging
Chapter A13: Atlas of Liver Biopsies
Chapter A14: Atlas of the Vasculitic Syndromes
Chapter A15: Atlas of Clinical Manifestations of Endocrine and Metabolic Diseases
Chapter A16: Atlas of Neuroimaging
Part 24: Clinical Procedure Tutorials
Chapter CP1: Clinical Procedure Tutorial: Central Venous Catheter Placement
Chapter CP2: Clinical Procedure Tutorial: Thoracentesis
Chapter CP3: Clinical Procedure Tutorial: Abdominal Paracentesis
Chapter CP4: Clinical Procedure Tutorial: Endotracheal Intubation
Chapter CP5: Clinical Procedure Tutorial: Percutaneous Arterial Blood Gas Sampling
Chapter CP6: Clinical Procedure Tutorial: Lumbar Puncture
Chapter CP7: Clinical Procedures Tutorial: Phlebotomy
Chapter CP8: Clinical Procedures Tutorial: Insertion of Female Urethral Catheter
Chapter CP9: Clinical Procedures Tutorial: Insertion of Male Urethral Catheter
Chapter CP10: Clinical Procedures Tutorial: Fine Needle Aspiration of Breast Cyst
Chapter CP11: Clinical Procedures Tutorial: IV Insertion
Chapter CP12: Clinical Procedures Tutorial: Fine Needle Aspiration of Thyroid Nodules
Chapter CP13: Clinical Procedures Tutorial: Gynecologic Examination with Pap Smear
Chapter CP14: Clinical Procedures Tutorial: Knee Arthrocentesis
Chapter CP15: Clinical Procedures Tutorial: Pericardiocentesis
Chapter CP16: Clinical Procedures Tutorial: Bone Marrow Biopsy
Chapter CP17: Clinical Procedures Tutorial: Basic Suturing

Editor’s Reviews on Harrison’s Principles of Internal Medicine 21st Edition PDF

McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide

Joseph Loscalzo, MD, PhD, is Hersey Professor of the Theory and Practice of Medicine at Harvard Medical School, Chairman of the Department of Medicine, and Physician-in-Chief at Brigham and Women’s Hospital.
Anthony S. Fauci, MD, is Chief of the Laboratory of Immunoregulation and Director of the National Institutes of Allergy and Infectious Diseases for the National Institutes of Health.
Dennis L. Kasper, MD, is William Emery Channing Professor of Medicine and Professor of Microbiology and Molecular Genetics at Harvard Medical School.
Stephen L. Hauser, MD, is Robert A. Fishman Distinguished Professor of Neurology and Director of the UCSF Weill Institute for Neurosciences for the University of California, San Francisco.
Dan L. Longo, MD, is Professor of Medicine at Harvard University School of Medicine and Deputy Editor of Oncology for the New England Journal of Medicine.
J. Larry Jameson, MD, PhD, is Robert G. Dunlop Professor of Medicine; Dean of Raymond and Ruth Perelman School of Medicine; and Executive Vice President of the University of Pennsylvania for the Health System.

Dennis L. Kasper, MD, MA (Hon)William Ellery Channing Professor of Medicine Professor of Microbiology and Molecular Genetics Executive Dean for Academic Programs Harvard Medical School Director, Channing Laboratory Department of Medicine Brigham and Women’s Hospital

Anthony S. Fauci, MD Chief, Laboratory of Immunoregulation Director, National Institute of Allergy and Infectious Diseases National Institutes of Health. In 2008, Dr. Fauci was awarded the Presidential Medal of Freedom, the Nation’s highest civil award.

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