Have you ever had any difficulty understanding that topic when you were in class? or the hospital? or in your office that was related to the subject of medicine and health. Well Alexander Disease A Guide for Patients PDF answers all those questions for you. You must give it a thorough read to understand what you probably are dealing with is related to human lives and allthingsmedicine is here to help you in that task. In this blog post we will share the download file for the book in pdf format. Cheers!
Attributes of Alexander Disease A Guide for Patients PDF
This book offers a comprehensive overview of Alexander disease, a rare and devastating neurological disorder that often affects the white matter of the brain and spinal cord. Alexander Disease A Guide for Patients PDF
Its distinctive neuropathology consists of abundant Rosenthal fibers within astrocytes (one of the four major cell types of the central nervous system). Nearly all cases are caused by variants in the gene encoding the intermediate filament protein GFAP, but how these changes in GFAP lead to the widespread manifestations of disease is poorly understood.
Astrocytes, while discovered over a century ago, are themselves still much of a mystery. They exhibit considerable diversity, defy precise definition, and yet actively regulate many aspects of nervous system functioning.
We also have incomplete understanding of Rosenthal fibers, odd structures that contain GFAP as just one of many components. Whether they are toxic or protective is unknown. Moreover, Rosenthal fibers are not absolutely unique to Alexander disease, and are seen sporadically in a wide variety of other conditions, including brain tumors and multiple sclerosis.
GFAP is the third unknown. It is an ancient protein, arising early in the evolution of vertebrates, but its role in normal biology is still a matter of debate. Yet Alexander disease shows, without a doubt, that changing just a single of its 432 amino acids can lead to catastrophe, not just in the astrocytes where GFAP is produced but also in the other cells with which astrocytes interact.
Despite all of the unknowns, much has been learned in the past 20 years, and it is time to share this knowledge. This book is intended for recently diagnosed patients and families, as well as non-specialist researchers interested in this neurological disease. It covers historical origins, the state of current knowledge, and prospects for what lies ahead, with citations to the primary literature given throughout.
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Illustrations of Alexander Disease A Guide for Patients PDF
For students and clinical professionals who are learning to better themselves in the field of their study. This book is the latest in its release and is a trademark of . This book is intended for recently diagnosed patients and families, as well as non-specialist researchers interested in this neurological disease.
Albee Messing, V.M.D., Ph.D., is Professor Emeritus of Neuropathology in the Department of Comparative Biosciences, School of Veterinary Medicine, and the past Director of the Waisman Center at the University of Wisconsin-Madison. Dr. Messing received his undergraduate degree in biology from Yale, and his veterinary and doctoral degrees from the University of Pennsylvania. He continued post-doctoral studies in experimental and clinical neuropathology at Penn under the tutorship of Nicholas K. Gonatas, M.D., and then joined the faculty at Wisconsin in 1985. He is the recipient of both the Weil and the Moore Awards from the American Association of Neuropathologists, was a Shaw Scholar of the Milwaukee Foundation, and delivered the Peter Lampert Memorial Lecture at UCSD in 2003, the Santiago Ramon y Cajal Lecture for the Spanish Neurological Society in 2010, and the Parisi lecture for the American Association of Neuropathologists in 2013. For over 20 years he has led an NIH-funded research program that is focused on understanding the mechanisms of Alexander disease and developing strategies for its treatment. He has served on the scientific advisory boards for the United Leukodystrophy Foundation and the Charcot-Marie-Tooth Association. He has published over 165 scientific peer-reviewed papers, reviews, book chapters, and books.
Proportions of Alexander Disease A Guide for Patients PDF
Publisher : Morgan & Claypool (November 14, 2017)
Language : English
Hardcover : 96 pages
ISBN-10 : 1615047646
ISBN-13 : 978-1615047642
Item Weight : 1.82 pounds
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