Attributes of Quantitative Biology of Endocytosis PDF
Quantitative Biology of Endocytosis PDF-Clathrin-mediated endocytosis (CME) is a ubiquitous internalization process in eukaryotic cells. It consists of the formation of an approximately 50-nm diameter vesicle out of a flat membrane. Genetics, biochemistry, and microscopy experiments performed in the last four decades have been instrumental to discover and characterize major endocytic proteins in yeast and mammals. However, due to the highly dynamic nature of the endocytic assembly and its small size, many questions remain unresolved: how are endocytic proteins organized spatially and dynamically? How are forces produced and how are their directions controlled? How do the biochemical activities of endocytic proteins and the membrane shape and mechanics regulate each other? These questions are virtually impossible to visualize or measure directly with conventional approaches but thanks to new quantitative biology methods, it is now possible to infer the mechanisms of endocytosis in exquisite detail. This book introduces quantitative microscopy and mathematical modeling approaches that have been used to count the copy number of endocytic proteins, infer their localization with nanometer precision, and infer molecular and physical mechanisms that are involved in the robust formation of endocytic vesicles.
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Illustrations of Quantitative Biology of Endocytosis PDF
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Julien Berro, Ph.D., is an assistant professor of Molecular Biophysics and Biochemistry, and of Cell Biology at Yale University. He initially trained in Physics, Applied Mathematics and Computer Sciences at the Institut National Polytechnique of Grenoble, France. He obtained his Ph.D. in Mathematical Modeling in Biology at Université Joseph Fourier, Grenoble, France, where he worked with Jean-Louis Martiel and Laurent Blanchoin on mathematical models for actin filament biochemistry and mechanics. After a brief tenure as an assistant professor in the department of Mathematics at Université Claude Bernard, Lyon, France, he decided to further his training by learning cell biology and quantitative microscopy in the laboratory of Tom Pollard at Yale University. Since he started his own laboratory in 2013, he has combined experimental, computational, and theoretical approaches to uncover the mechanisms of molecular machineries that produce forces in the cell, with a particular focus on the actin cytoskeleton and endocytosis.
Michael M. Lacy, Ph.D., completed his dissertation research in the laboratory of Prof. Julien Berro at Yale University. He earned his B.S. degree in Biochemistry at Tufts University in 2012 and his Ph.D. in Molecular Biophysics and Biochemistry at Yale in 2018, and he is now a postdoctoral researcher in the Berro laboratory before he leaves to launch his career in scientific editing and communication. Mike began the first stage of his Ph.D. research in the laboratory of Prof. Elizabeth Rhoades where he studied intrinsically disordered proteins. Mike’s research in the Berro laboratory has developed and used single-molecule fluorescence microscopy to study membrane remodeling, focusing on the actin cytoskeleton and endocytosis in yeast. Mike was an editor for the Yale Journal of Biology and Medicine from 2014 to 2018, and he has been a member of the Biophysical Society since 2013. In his spare time, he enjoys bicycling, playing softball, and homebrewing beer.
Dr. Wallace F. Marshall is Professor of Biochemistry and Biophysics at the University of California San Francisco. Dr. Marshall’s research focuses on understanding how the complex geometry of cells arises from the interplay of molecular and physical mechanisms, as well as how cell geometry relates to cell function. His lab has a particular interest in the mechanisms that control the size of organelles. Questions of cell geometry are inherently quantitative, and Dr. Marshall’s group employs an integrated combination of quantitative microscopy, image analysis, and computational modeling, together with genetic and biochemical methods.
Dr. Marshall received Bachelor degrees in Electrical Engineering and Biochemistry at the State University of New York, Stony Brook, and his Ph.D. in Biochemistry at the University of California San Francisco. After postdoctoral training at Yale University in the Molecular, Cellular, and Developmental Biology department, he returned to UCSF in 2003 to start his faculty position. He has been an organizer of the Cold Spring Harbor Computational Cell Biology conferences for the past three years and is currently co-director of the Physiology course at the Marine Biological Laboratory in Woods Hole, MA.
Proportions of Quantitative Biology of Endocytosis PDF
- 出版者 : Morgan & Claypool Life Sciences (25 7 月 2018)
- 語言 : English
- Paperback : 86 頁
- International Standard Book Number-10 : 1615047840
- International Standard Book Number-13 : 978-1615047840
- 尺寸 : 19.05 x 0.46 x 23.5 cm
- Book Name :Quantitative Biology of Endocytosis PDF
Reviews From Customers
REstor “I used Leik’s as my main reviewer when I took my exam on Aug. 29,2019. I did the AANP and I passed!
Anyhow, what i like about this book is that it gives you more information on the details of each diseases, which I think is so important for you to comprehend on the disease process. In addition, Leik also does a great job in giving you clinical pearls and important things to remember, not only for the exam, but also when you become a nurse practitioner.
Yes, I agree there are some errors in this book but there is not a perfect reviewer out there. The cost of this book is very affordable and it is information loaded. I highly recommend this book.
Tips for the exam:
To be honest, I just did an extensive 3 weeks review for my certification exam. I had to lay low on my second job, but just working my full time 3 12hrs shift. So during my 4 days off, I would just concentrate on reading as much info as i can. I usually read from 1 or 2pm till 12mn or 1am, but i make sure that before I read, I would run/jog or do some exercises to relax my brain and destresses my body. That I think is most helpful before the review. After I read the whole book, I did Leik’s questions, 30 at a time and I was downhearted coz I would always get below 70%, but there are times I would get over 90%. Those exams below 70% motivated me to do even better. I would re-read the info so I can understand it better.
The day I took the exam, I marked 114 unsure answers. Most of my questions are cardiac, pediatric, and geriatric. I had a very hard time at the exam and just going over to my marked numbers. As I went through to re-read the marked items, I caught myself changing some of my answers and that was the time I had to stop myself from changing answers because it was a pointless thing to do. I finished the exam with just 3 minutes, I felt beaten, exhausted, and thought I failed the exam.
I went out of the room and the proctor printed my preliminary results. It was two sheets and I told myself that that is why they were two sheets because it would tell me my weak points, but I was wrong.
So here’s my advice, 1. have a clear mind when you review, 2. stay away from things that stresses you. For me, I turned of my social media because I felt insecure seeing my classmates passed and it doesn’t do my any good at all.
3. Do exercises to destress your body. 4. Practice exam questions. 5. Have a real good sleep the night before the exam. 6. On the day of the exam, do not cram on reading the questions, read them carefully and mark the items you are unsure of ( do not be afraid to mark several of them). 7. Do not be afraid for God is with you always ( this really helped me a lot during the exam).
You can do it! I know you can. Cheers to your future success”
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