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Attributes of Nanotherapeutics in Cancer Vaccination and Challenges PDF
Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and promising avenues. The book covers cancer vaccines before exploring nanotherapeutics, DNA and mRNA vaccines in cancer treatment. Finally, it considers regulatory and industrial perspectives on cancer vaccination and nanotherapeutics. This resource will be useful for pharmaceutical scientists and researchers focused on biomedical engineering, chemical engineering, vaccine development, and cancer immunotherapy, along with advanced students in these subjects. Cancer is arguably the most complex and challenging disease known to mankind. Over the last two-decades, significant advancements have been made in new and novel concepts of cancer nanomedicines. Therapeutic cancer vaccines may be utilized to inhibit further growth of advanced cancers and/or relapsed tumors that are refractory to conventional therapies, such as surgery, radiation therapy and chemotherapy.Nanotherapeutics in Nanotherapeutics in Cancer Vaccination PDF
Presents the progress made in cancer medicines from conventional to targeted therapy
Covers the present state-of-the-art of cancer nanomedicines and upcoming therapeutic cancer vaccination
Contains a focus on advanced nanomaterials that are utilized for encapsulation of nucleic acid, mRNA, DNA, siRNA
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Illustrations of Nanotherapeutics in Cancer Vaccination and Challenges PDF
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Contents of the Textbook
Title page
Table of Contents
Copyright
Dedication
List of contributors
Preface
Acknowledgments
Chapter 1. Cancer vaccines: past, present, and future
1. Introduction
2. Cancer vaccines and their applications
3. Smart carriers in cancer vaccine delivery
4. Key challenges: formulation challenges and regulatory hurdles
5. Conclusion and future perspectives
Chapter 2. Inorganic nanoparticulate carriers in management of cancer: theranostics and toxicity apprehension
1. Introduction
2. Inorganic nanoparticles
3. Advantages of inorganic nanoparticle
4. Application of inorganic nanoparticles in cancer treatment
5. Conclusion
Chapter 3. Recent developments in cancer vaccines: where are we?
1. Introduction
2. Vaccines and their mechanism of action
3. Classification of cancer vaccine
4. The fundamental mechanism of antitumor immunity
5. Cancer and its types
6. Present cancer treatments
7. Significance of the development of cancer vaccine
8. Known or possible targets for the development of cancer vaccines
9. Current status on the development of cancer vaccines
10. Future perspectives of cancer vaccines
11. Conclusion
12. Conflict of interest
Chapter 4. Application of nanotechnology assisted devices in cancer treatment
1. Introduction
2. Nanotechnology in cancer
3. Devices based on nanotechnology
4. Nanotechnology and medical devices
5. Emerging medical devices using nanotechnology for cancer therapy
6. Challenges and regulations
7. Advantages and disadvantages of nanotechnology in cancer
8. Conclusion
9. Conflict of interest
Chapter 5. Advancement in protein-based nanocarriers in targeted anticancer therapy
1. Introduction
2. Protein-based nanocarriers in targeted drug delivery
Chapter 6. Elastic liposomes as transcutaneous DNA vaccine vectors
List of abbreviations
1. Introduction: brief history of vaccinology and focus on DNA vaccines
2. Need for targeted DNA vaccines
3. Liposomes as DNA vaccine vectors
4. The skin as an immunization route
5. Topical application of DNA vaccines and optimization of material delivery through colloidal vectors
6. Conclusions
Chapter 7. Nanotechnology-based manipulation of dendritic cells for enhanced immunotherapy strategies
1. Introduction
2. Mechanism of action conciliated by the interaction between nanoparticles (NPs) and dendritic cells (DCs)
3. Potential change in pharmacological effects
4. Potential effects of NPs on DCs
5. Conclusion
Chapter 8. Peptide-based anticancer targeted therapeutics: state of the art
1. Introduction
2. Peptide-based anticancer targeted therapeutics
3. Future perspectives and conclusion
Chapter 9. Polyplexes-based delivery systems for cancer vaccine delivery
1. Introduction
2. Cancer vaccines
3. Nanotechnology based carrier system for cancer vaccine delivery
4. Polyplexes
5. Characterization of polyplexes
6. Applications of lipoplexes and polyplexes
7. Conclusion
Chapter 10. Lipopolyplex-based delivery system for cancer vaccine delivery
1. Introduction
2. Lipopolyplex structure and physicochemical properties
3. Types of cancer vaccine
4. Therapeutic cancer vaccine targeted delivery
5. Advantages of lipopolyplex based delivery
6. Limitations
7. Conclusion
Chapter 11. Inorganic nanoparticulate carriers in cancer vaccination
1. Introduction
2. Cancer immunotherapy
3. Nanomedicine: unmet need in cancer immunotherapy
Chapter 12. Functional nanomaterials and nanocomposite in cancer vaccines
1. Generally employed vaccines and antigens for anticancer therapy
2. Identified tumor-associated antigens
3. Whole tumor cells or tumor lysates
4. DNA vaccines
5. Subunit peptide vaccine
6. mRNA vaccine
7. Personalized vaccine and neoantigen
8. Functional nanomaterials
9. Liposomal nanovaccine
10. PLGA nanovaccine
11. Dendrimers nano vaccine
12. Approved cancer vaccines: for treatment and prevention
13. Cancer vaccines approved for chemoprevention [68]
14. Conclusion
Chapter 13. DNA vaccines for cancer treatment: challenges and promises
1. Introduction
2. Nano-carriers for transfer of DNA vaccines
3. Conclusion
Chapter 14. mRNA-based nanovaccines as newer treatment modalities in cancer
1. Introduction
2. mRNA nanovaccines in cancer: stability manifestations
3. mRNA-based nanoparticulate systems
4. Conclusion and future perspectives
Chapter 15. Cancer immunotherapy: moving forward with peptide T-cell vaccines
1. The concept: immunotherapy in cancer
2. Peptide-based cancer vaccines: types and examples
3. Selection of delivery systems for peptide T-cell vaccines
4. Challenges in optimization of peptide vaccines
5. Peptide-based vaccines in clinical trials
6. Future of peptide-based cancer vaccines
Chapter 16. Product development and scale-up challenges in cancer vaccine development
1. Introduction
2. Vaccine for cancer therapy
3. Mode of action of therapeutic vaccines
4. Vaccine vectors
5. Development pathway of cancer vaccines
6. Clinical trials of cancer vaccines
7. Approved therapeutic cancer vaccines
8. Adjuvant therapy
9. Regulatory framework for development of cancer vaccines
10. Scale-up and challenges of cancer vaccine
11. Conclusion
Chapter 17. Regulatory landscape in the approval of cancer vaccine
1. Introduction
2. Background in the approval of cancer vaccine
3. Regulatory considerations
4. Quality considerations
5. Nonclinical considerations
6. Clinical considerations
7. General vaccine approval process by regulatory body
8. FDA requirements on cancer
9. Regulatory guidance of FDA to admit the approval of cancer vaccine
10. Regulatory guidance of European regulatory system to admit the approval of cancer vaccine
11. Regulatory guidance of PMDA (The Pharmaceuticals and Medical Devices Agency by Govt. of Japan) admit the approval of cancer vaccine in Japan
12. Various guidelines for cancer vaccine in remaking world
Chapter 18. Cross-presentation-based nanovaccine for cancer immunotherapy
1. Introduction
2. Understanding the concept of antigen cross-presentation
3. Targeting DC subsets for enhancing cross-presentation
4. C-type lectin receptors (CLRs) for targeted delivery
5. TLRs and their adjuvant activity
6. Plant lectins as a new player in targeted nanovaccine development
7. Liposomes as nanocarrier for antigen delivery
8. Advancing cancer immunotherapy using next generation glyco-nanovaccine
9. Advancing next generation anticancer nanovaccine development
10. Conclusion and future perspectives
Chapter 19. Immunotherapy-based cancer vaccines: state of the art
1. Introduction
2. T cell-based cancer immunotherapy
3. Types of T-cell vaccines
4. Conclusion
Chapter 20. Therapeutic peptides in anticancer therapy
1. Introduction
2. Cell-penetrating and tumor-targeting peptides
3. Nanomedicine-peptide complexes for cancer therapy
4. Conclusion and future perspectives
Chapter 21. Inorganic nanoconjugates for cancer theragnosis
1. Introduction
2. Inorganic nanoparticles in cancer therapy and vaccination
3. Conclusion and future perspectives
Index
The Writers
Mahfoozur Rahman, PhD, is an Assistant Professor at the Department of Pharmaceutical Sciences, Faculty of Health Science, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Allahabad, India. His major areas of research interest include development and characterization of nanosized drug delivery systems for inflammatory disorders including psoriasis, arthritis, neurodegenerative disorders and cancer, etc. Besides, he is also working on amalgamation of herbal medicinal plants with modern therapeutics in order to deliver a scientifically acceptable therapy for various diseases management. To date he has published over 100 publications in peer reviewed journals.
Affiliations and Expertise
Assistant Professor, Department of Pharmaceutical Sciences, Faculty of Health Science, Sam Higginbottom University of Agriculture, Techn
Proportions of Nanotherapeutics in Cancer Vaccination and Challenges PDF
- No. of pages: 494
Language: English
Copyright: © Academic Press 2022
Published: March 3, 2022
Imprint: Academic Press
Paperback International Standard Book Number: 9780128236864
eBook International Standard Book Number: 9780128236871
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