Features of Manual of Clinical Microbiology 12th Edition PDF
Manual of Clinical Microbiology 12th Edition PDF-Revised by a collaborative, international, interdisciplinary team of editors and authors, this edition includes the latest applications of genomics and proteomics and is filled with current findings regarding infectious agents, leading-edge diagnostic methods, laboratory practices, and safety guidelines. This edition also features three new chapters on accreditation, Mycobacterium tuberculosis complex, and human herpesvirus 8. This seminal reference of microbiology continues to set the standard for state-of-the-science laboratory practice as the most authoritative reference in the field of microbiology.
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Description of Manual of Clinical Microbiology 12th Edition PDF
Manual of Clinical Microbiology 12th Edition PDF is one of the best medical books for students and professionals on the subject of Infectious Diseases. It is a must download.
“I just always loved science. As far back as I can remember, I knew I would be a medical doctor working in science. I immersed myself in science in elementary and high school, participating, for example, in science fairs, which, in Canada, are structured a little differently than in ‘the States.’ I did a lot of work on my own; my projects were quite homemade, performed, for the most part, in my basement. There was no formal collaboration with any particular outside vendor, though my parents were supportive, even if I made a big mess of their house; one of the highlights was that I got to go to the Canada-Wide Science Fair, which, for a student working out of their basement, was exciting.
Patel returned to Canada for medical school, entering McGill University in Montreal on a full scholarship. Her intention was to complete postgraduate training in the United States and then return to Canada to practice. Those plans obviously changed upon her ultimate decision of training location. She recollected, “I interviewed at a number of places on the East Coast and in the Midwest. I didn’t have a lot of resources, so I applied to places within driving distance. [Mayo Clinic] was a different interview than those I had experienced at any of the other places that I looked at, and that was what made up my mind; there was a distinct focus.” Mayo Clinic has been characterized by some (2, 4) as being rather unique for its patient-centered philosophy, even with respect to diagnostic and basic science paradigms. One past doctoral student of Patel (whose professional affiliation restricted them from going on record but hereby is gratefully acknowledged for their contribution to this biographical feature) related that the unique opportunity of rounding with Patel (on transplant infectious diseases) was experienced on multiple occasions. One thing that was learned from observing Patel in this role was the belief that (hospitalized) patients were most often the best source of information for what was going on with their cases; Patel essentially instilled the fact that directly asking at the source is generally the most efficient approach.
Patel decided upon internal medicine residency training at Mayo Clinic because it allowed the opportunity to “dive deep” into other areas of medicine (one of which was infectious diseases, for which she completed fellowship training at Mayo Clinic in 1995). Again, because her original intention was to return to Canada, and because in Canada (Québec, in particular) many infectious diseases practitioners are also clinical microbiologists (similar to the British system), she decided to additionally complete a clinical microbiology fellowship (by way of an American Board of Pathology training program) at Mayo Clinic in 1996. In the end, Patel learned that she “absolutely loved clinical microbiology. Clinical microbiology seemed like the perfect area where I could work in science and medical practice, making a difference with laboratory science and bringing research to the table as well. That experience would forever change my career.”
Patel was already engaged in nondedicated research time during residency training and published nearly two dozen manuscripts prior to her first academic appointment at Mayo Clinic in 1996. Her research career began to explode during her infectious diseases fellowship under the tutelage of Carlos Paya, M.D. Dr. Paya was a virologist by trade, and Patel “cut her teeth” on cytomegalovirus (5, 6). Patel recalled, “It was the early 1990s when the field of transplant infectious diseases was being birthed. Mayo Clinic was one of the first places to have a formal clinical transplant infectious diseases program; the opportunity to study infectious diseases in this patient population was unprecedented. Much of what we know to be true today was in the process of being learned back then. [Dr. Paya] was a natural person for me to work with and to train me in laboratory-based but, at the same time, translational research; this molded my career.” This notes one early example of a paradigm that has been consistent throughout Patel’s career: applying skills as a basic scientist to clinical needs in the field.
With Mayo Clinic being one of the early leaders in transplant infectious diseases, it also was one of the first clinical locations to recognize the importance of vancomycin-resistant Enterococcus spp. (VRE) in transplant populations (7). Patel recollected, “We were able to track the first introduction and spread of VRE into our health care institution, in addition to understanding VRE therapeutics, all because of our transplant program, which is where I had cut my teeth in translational research.” As a result, she was instrumental in developing assays to detect vancomycin resistance in these organisms, described a new vancomycin resistance gene in enterococci (8), and defined a homolog to vancomycin resistance genes in enterococci in the biopesticide Paenibacillus popilliae (9). Patel concluded, “For me, it started off as just another type of infection affecting the patients I was seeing (the transplant patients) and then became a really interesting scientific area.”
Upon full-time faculty appointment, Patel assumed directorship of the infectious diseases research laboratory at Mayo Clinic, largely on account of a desire of her collaborator, Dr. James Steckelberg, to return to clinical practice. She continued a strong collaboration with Dr. Steckelberg relative to his long-standing interests in bone and joint infections (10) and endocarditis (11). Bone and joint infection research was of heightened interest because Mayo Clinic had introduced an orthopedic infectious diseases clinical service to complement a large orthopedic surgery referral service. As time progressed, the frequency of arthroplasty procedures increased, and the entity of periprosthetic joint infection had become commonplace. In the words of Patel, colleagues approached her claiming that this was “essentially a new disease, but we are using the same diagnostics that we had been using for native joint infection. We have gaps in this field, and we think that someone like you, who is trained in clinical microbiology and translational research, could help come up with better ways of diagnosing and treating periprosthetic and other orthopedic implant-associated infections.”
At the same juncture, Patel’s research laboratory was busy characterizing medical biofilms, relative to organisms including Staphylococcus lugdunensis (12), Candida albicans, and Pseudomonas aeruginosa. Patel then reasoned (with growing exuberance in her voice), “Wow, if we take the understanding of biofilms that is coming from environmental microbiology—more so than medical microbiology—and put that together with what is happening with orthopedic implant-associated infections, I think we stand a chance of being better to understand what is going on and probably to come up with better diagnostics and therapeutics. So, I listened to my colleagues, and I reasoned, ‘I think this is a field that needs improvement; I am going to try to make a difference.’” The convergence of these events resulted in, according to Shawn Vasoo, MBBS, MRCP (clinical director, head of infectious diseases research laboratory, National Centre for Infectious Diseases, Singapore), “seminal work on biofilm-associated infections, particularly sonication of prosthetic orthopedic devices for infections (13) and in further defining how these should be applied clinically.” Elitza S. Theel, Ph.D., director, infectious diseases serology laboratory at Mayo Clinic, concurred, “Dr. Patel’s most influential work has really revolved around improving diagnostics for prosthetic joint infections. This includes both her innovative work around sonication of explanted prosthetic joints to increase the recovery of bacteria and, more recently, the application of metagenomics for identification of the more difficult-to-detect pathogens.”
Patel also chairs the Division of Clinical Microbiology in the Department of Laboratory Medicine and Pathology at Mayo Clinic. Thomas F. Smith, Ph.D. (4), emeritus chair of the Division of Clinical Microbiology at Mayo Clinic, wrote, “Dr. Patel is an iconic physician who, as chair of the Division of Clinical Microbiology, leads a very talented group of microbiologists. She encourages their development by her independent skills of outstanding writing and appreciation of collaboration with clinical colleagues (she also appreciates the connective and translative role of a clinical microbiologist with the practice of medicine) and focus on an extremely strong work ethic.” Alexander J. McAdam, M.D., Ph.D., current editor in chief of Journal of Clinical Microbiology, wrote that Patel is able to recognize and implement promising new methods very quickly. “She was among the first in the United States to see the potential of matrix-assisted laser desorption ionization–time of flight mass spectrometry for microbiology (14) and was a leader for introducing this method into clinical use.”
Not to be lost in the realm of clinical microbiology and translational research is the potential contribution of the bench technologist. Patel opined, “Bench technologists can become better bench technologists by desiring to become better bench technologists, by being interested in what they are doing, and by asking probing questions. Questioning and having an open eye can make a difference.” She noted that important findings and changes in laboratories can emanate not only from the laboratory director but also from a bench technologist. Patel then related a story of how one esoteric plate finding from a bench technologist translated into a multicenter investigation that linked high serum levels of ammonia in lung transplant recipients with Ureaplasma infection, rendering an often-fatal disease curable (15). She additionally offered her opinion that clinical microbiology is in the midst of a massive technology revolution. As a result, some testing may leave the physical microbiology laboratory for other clinical settings, such as at the point of care. With that, she warned, “There remains a need for our medical science expertise; we should lead the science” and followed up by remarking that “we’re able to do so many things today that we could never do 10 or 15 years ago. Our practice will continue to change; it is just so exciting to think about how we’re going to increasingly make a difference in patient care.”
Commitment to clinical and translational research is further exemplified by more than 450 peer-reviewed publications, a larger number of abstracts, and nearly two dozen book chapters. She is also listed on two United States patents related to her work on biofilms as well as a direct detection method for Bordetella spp. Patel’s laboratory currently has stewardship or costewardship over 9 federal grants or subawards, 12 industry grants, and 4 institutional awards. She has been bestowed with numerous honors, including fellowship in the American Academy of Microbiology in 2012, the BD Award for Research in Clinical Microbiology in 2015, and the Mayo Medical School Distinguished Service Award.
Patel has fulfilled a second major component of the academic triad, namely, teaching, in robust fashion. When asked to comment about Patel, Dr. Gilligan cited her directorship of the medical microbiology course at the Mayo Clinic Alix School of Medicine. “She gets people excited about clinical microbiology. I, myself, have learned much about teaching from her.” Patel first taught in the course as a fellow and has directed this course since 2001. She shared, “I love to teach. In medical science, there is a culture of education. We always have trainees, and we are always teaching the next generation; at the same time, I learn so much from the students. I particularly enjoy working with students who are learning something for the first time or in a new way and will take that knowledge and apply it in the world and probably advance it at the same time.” Advancements in technology have altered the means of medical student education over the years; Patel largely sees herself nowadays in the role of a facilitator or tour guide. “Different learners prefer to learn in different ways, and that comes back to the tour guide analogy; we just need to make sure everybody on the tour is staying with the program and learning what they’re supposed to be learning. It is fine if each learner gets there in slightly different ways.”
Patel’s commitment to teaching extends into mentorship. Her provided curriculum vitae lists 14 pages’ worth of students who have worked or completed projects in her research laboratory. Her curriculum vitae itemizes papers (which number in the dozens) in which the primary author was a Patel mentee. She summarized her research mentorship philosophy as such: “In my research laboratory, there’s a culture of having people from all over the world train as part of our laboratory team. We have had laboratory members—I call them laboratory family members—from Asia, Australia, Latin America, Europe, Canada (anywhere, really). I have Ph.D. students, medical students, postdocs, and so forth; for me, it’s a natural way of doing research—we do research, we train people to do research, and we all learn together, leveraging my experience from the past, to move in a good direction together. A key component of my research team is the three research technologists, Kerryl Greenwood-Quaintance, Melissa Karau, and Suzannah Schmidt-Malan, who have been part of my team for 25, 15, and 10 years, respectively.”
The previously mentioned doctoral trainee of Patel related the experience of how, for a Ph.D. student (rather than a medical student or fellow), an extended-duration and more substantive research project would have to be devised. Patel conceived a new, appropriately sized project seemingly overnight. Bobbi S. Pritt, M.D., director, clinical parasitology laboratory at Mayo Clinic, and an editor for the Journal of Clinical Microbiology, was also a clinical microbiology fellowship trainee at Mayo. She wrote, “Right from the start, Dr. Patel challenged me to think independently and use the results of my own literature review and analysis of the data to answer clinical questions.” Patel’s accommodating style is conducive to these relationships. Dr. Vasoo commented, “Despite being very busy, I was personally very touched by how she always made time for her fellows. We would meet weekly, one on one, and it would be dedicated time for us to discuss issues with research or with training, to ask questions, and to catch up. That’s been something which has profoundly influenced me and how I relate to and mentor trainees.” Dr. Theel added that during her one-on-one fellowship interview with Patel, “I remember being amazed at how focused she was on me and on what I was saying, despite her pager buzzing, her phone ringing, and her email inbox filling. I realized then that she is the type of individual who, once dedicated to something, does not get easily distracted and sees it through to completion.”
Patel segued into a third pillar of the academic triad (service) by opining, “When you’re at your institution running your laboratory and things are going well, you look for other ways to contribute to the field (and learn at the same time), such as serving the government, societies, and other groups.” She is director of the National Institutes of Health (NIH) Laboratory Center for the NIH’s Antibacterial Resistance Leadership Group (16) and an advisor to the Clinical and Laboratory Standards Institute Subcommittee on Antimicrobial Susceptibility Testing (17). She is also a past chair of the U.S. Medical Licensing Examination Microbiology and Immunology Test Material Development Committee. Patel served as an associate editor for Journal of Clinical Microbiology from 2009 to 2019, currently serves as an associate editor for Clinical Infectious Diseases, has served as an editorial board member for Clinical Microbiology Reviews and Antimicrobial Agents and Chemotherapy, and is a volume editor for the Manual of Clinical Microbiology 12th Edition PDF.
With all of that said, perhaps Patel’s most renowned contributions to professional societies (particularly the American Society for Microbiology [ASM]) have been in the form of leadership. Dr. Thomson wrote, “Robin has been instrumental in establishing the sound scientific focus of clinical microbiology … as a chair of many professional committees, she easily solicits broad participation, ensures accomplishment of all tasks, and is appreciative of everyone’s efforts.” One of Patel’s first major ASM leadership contributions involved her two stints on the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Program Committee (from 2002 to 2007 and from 2012 to 2015).
To conclude, besides the general realm of science motivating Dr. Robin Patel along her career path, one also returns to the patient-centered experience as a motivating factor. She explained, “When you know that what you are doing could potentially make someone’s life better or save a life, that’s highly motivating. We can see it—small but incremental findings that make a difference. We’ve done things and found things that have clearly changed people’s lives or even saved them. That sounds pretentious, I know, but it’s true, and there is just nothing more fulfilling or motivating than that. Of course, that type of thing doesn’t happen every day; it’s a process to get there, but you don’t arrive unless you start.”
Dimensions and Characteristics of Manual of Clinical Microbiology 12th Edition PDF
- Publisher : ASM Press; 12th edition (February 20, 2019)
- Language : English
- Hardcover : 2832 pages
- International Standard Book Number-10 : 1555819834
- International Standard Book Number-13 : 978-1555819835
- Item Weight : 13.28 pounds
- Dimensions : 8.8 x 3.8 x 11.2 inches
- Book Name : Manual of Clinical Microbiology 12th Edition PDF
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Michael “I was surprised to see a Kindle version offered of the 12th Edition of the Manual of Clinical Microbiology. I have the 11th edition, but even the publisher (ASM Press) has not offered the 12th edition electronically yet.
After purchasing this as a kindle book, the icon in my app showed the cover of the 12th edition. But when I opened it, the cover photo and front material all showed this to be the 11th edition! Which I already have! I immediately initiated a return.
I hope the 12th edition is available electronically soon, but apparently at the time I am writing this review, this is not it.
The fact I did not get the book I wanted should earn 0 stars for the purchase, but since it’s a review of the product itself, I guess I have to give it the 5 stars the actual book deserves.”
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