Page Contents
Attributes of Dietary Phosphorus: Health, Nutrition, and Regulatory Aspects PDF
Phosphorus is an essential nutrient that occurs in almost all foods and is important for many normal physiological functions. In a typical Western diet, it is not harmful, but does adversely affect tissues in the body when consumed in excess or deficiency. This book provides a comprehensive review of various aspects of phosphorus in relation to human nutritional needs. Sections cover phosphorus nutrition and dietary issues; health risks associated with excess phosphorus intake that exceeds requirements; phosphorus intake in populations at risk; regulatory challenges and policy approaches; and environmental impacts of phosphates in the modern food supply. Dietary Phosphorus: Health, Nutrition, and Regulatory Aspects PDF
This book challenges the long held ideas that high dietary phosphorus intake beyond nutritional requirements is safe and the natural supply of phosphorus critical to agricultural and human food production is endless. Controversy surrounds the claim that largely unrestricted use of phosphorus in all aspects of food production from farm to fork increases dietary phosphorus intake and irretrievable environmental loss, both of which harm human and environmental health. The book editors have joined together experts in basic, medical, environmental, nutritional, and food science to explore the validity of these claims of harm from high intakes and the unchecked use of phosphorus in the global food supply. Despite the essential need for adequate phosphorus over all stages of plant, animal and human life, the growing evidence points to a worldwide increase in dietary phosphorus intake far beyond nutrient requirements, significant association with chronic disease risk even when renal function is not compromised, and the increase in environmental loss with crop run-off, animal husbandry, and unretrieved phosphorus from human waste. This current evidence alludes to a depleted, unsustainable natural supply of phosphorus, hazardous environmental pollution of lakes and waterways, and significant increases in the risk of kidney, skeletal, and other serious illnesses in humans in the future if action is not taken now.
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Illustrations of Dietary Phosphorus: Health, Nutrition, and Regulatory Aspects PDF
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The Writers
Jaime Uribarri, MD Dr. Jaime Uribarri is a physician and clinical investigator. He was born in Chile and received his medical degree from the University of Chile School of Medicine. He did all his postgraduate training in the United States. He has been in The Icahn School of Medicine at Mount Sinai, New York, since 1990, where he is currently Professor of Medicine and Director of the Renal Clinic and the Home Dialysis Program at the Mount Sinai Hospital. In parallel with his clinical activities, Dr Uribarri has been very active in clinical investigation for the past 30 years. His main areas of research have been on acid–base and fluid and electrolyte disorders, as well as nutrition in chronic kidney disease and diabetic patients. He was one of the first to bring attention to the important role of food-derived advanced glycation end products (AGEs) in chronic diseases in humans. He has published over 150 peer-reviewed papers and written many chapters in books. He has lectured extensively on these research topics in New York City, as well as in national and international meetings. He serves as an ad hoc referee for numerous nutrition, medical, and other scientific journals, and he is an active member of several health organizations and professional associations, including The American Society of Nephrology, The American Society of Nutrition, The International Society of Nephrology, The New York Academy of Sciences, and The Maillard Society.
Mona S. Calvo, PhD After earning a doctorate in Nutritional Sciences from the University of Illinois, Champaign-Urbana, Dr. Calvo pursued postdoctoral studies in the Endocrine Research Unit of the Mayo Clinic in Rochester, Minnesota. Recently retired from the Food and Drug Administration (FDA) after 28 years, her former position and title was that of Expert Regulatory Review Scientist and Research Principal Investigator at the FDA’s Center for Food Safety and Applied Nutrition. Her current and past research interests focus on dietary influences on the hormonal regulation of calcium, phosphorus, and vitamin D and their impact on bone and kidney disease and other chronic diseases of public health significance. These research interests have been the topics for over 150-peer-reviewed manuscripts, book chapters, government reports/guidelines, FDA regulations, and abstracts presented at national and international meetings. She serves as an Associate Editor for Public Health Nutrition; an ad hoc referee for numerous nutrition, medical, and other scientific journals; and is a member of the Endocrine Society, American Society for Nutrition, the Nutrition Society (UK), and the American Society for Bone and Mineral Research and serves as a member of the advisory board for ODIN, which seeks food-based solutions for optimal vitamin D nutrition and health through the life cycle.
Proportions of Dietary Phosphorus: Health, Nutrition, and Regulatory Aspects PDF
- Identification Number : B075YZT6S7
- Publisher : CRC Press; 1st edition (September 27, 2017)
- Publication date : September 27, 2017
- Language : English
- File size : 13790 KB
- Simultaneous device usage : Up to 4 simultaneous devices, per publisher limits
- Text-to-Speech : Enabled
- Screen Reader : Supported
- Enhanced typesetting : Enabled
- X-Ray : Not Enabled
- Word Wise : Not Enabled
- Print length : 388 pages
- Dietary Phosphorus: Health, Nutrition, and Regulatory Aspects PDF
Reviews From Customers
Kenneth R. Phelps, M.D.
We need phosphate for everything and the supply is limited.
August 8, 2018
I am submitting this review as a nephrologist with an interest in phosphate homeostasis. My comments are intended for fellow physicians and other health-related professionals.
Dietary Phosphorus: Health, Nutrition, and Regulatory Aspects examines a remarkably broad scope of topics. It comprises 24 digestible chapters, each of which is authored by at least one recognized expert. The extensive citations at the end of each chapter are an excellent resource.
The book is divided into three major sections: “Health issues associated with dietary phosphorus intake,” “Dietary phosphorus intake and nutritional needs,” and “Food and environmental use and regulation of phosphorus.” Despite the diversity of topics, those who read the book from cover to cover will encounter similar synopses of phosphate homeostasis in multiple chapters. Although the redundancy may seem inefficient and unnecessary, it facilitates emphasis on aspects of homeostasis that are most relevant to a given topic, and it benefits readers who wish to inform themselves about a specific issue without reading multiple chapters. I agree with this approach.
Section 1 contains ample information about phosphorus balance, tubular handling of phosphorus, bone physiology, and related endocrine issues. For me, the chapter by Dusso and colleagues on phosphorus and vitamin D metabolism stands out. In some respects, however, the chapters on end-organ effects of phosphorus could be improved. It isn’t always clear whether “excessive” phosphorus refers to dietary intake or the plasma concentration. The latter is often the critical variable, especially in determination of cardiovascular morbidity and mortality, and intestinal absorption is not the only relevant flux. It is likely that reabsorption also contributes importantly to concentrations that impart risk, especially when the glomerular filtration rate is normal, but this issue is not addressed. Similarly, although phosphate concentrations vary substantially through the day, the chapters on end-organ effects skirt this issue, and the reader is left to wonder what concentration (at what time of day) promotes morbidity.
In recent years, two phosphate-related subjects have preoccupied clinicians who care for patients with chronic kidney disease. The first is the ubiquitous presence of highly absorbable phosphate-containing preservatives in current Western diets. The second is the therapeutic advantage conferred by limited phosphate bioavailability in plant sources. In Section 2, multiple well-written chapters are devoted to these issues. In addition, Bonjour makes the interesting point that phosphate supplements may be required in patients receiving anabolic therapy for osteoporosis, and Gutierrez summarizes the evidence that low socioeconomic status leads to a phosphate-rich diet. The chapter by Tiselius on the contribution of phosphate to stone formation is excellent.
Before reading this book, I was almost completely ignorant of the material in Section 3. Nevertheless, I found the accepted methods for determining the estimated average requirement (EAR) and recommended daily allowance (RDA) of phosphorus to be very debatable (Calvo and Whiting), and I am stimulated to learn more about these issues. I had never wondered where phosphate comes from or how it reaches the food that we eat; I did not know that global supplies are finite, nor did I know that most phosphate mined for our ultimate consumption is irretrievably wasted. Other equally ignorant readers will benefit greatly from the two fascinating chapters on phosphate ecology.
I enthusiastically recommend Dietary Phosphate to colleagues for its physiologic, clinical, regulatory, and ecological insights. I salute the editors for their astute selection of topics and their recruitment of distinguished contributors. I expect to use the volume often as an essential reference.
J. Rein
Phosphorus in excess can contribute to poor health.
December 8, 2017
Phosphorus in excess can contribute to poor health. Much of dietary phos is added as preservatives in processed food. This authoritative textbook is edited by two leading experts in the field and the chapters provide great insight. A must have for anyone interested in nutrition and health!
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