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Cell Signaling Pathways in Development PDF Cell Signaling Pathways in Development, Volume 149 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Ephrin signaling, Cell signaling to the extracellular matrix, Signaling by TGF-b superfamily members, Hedgehog signaling, Parallels in signaling during development and regeneration, Hippo signaling, Wnt/PCP signaling, Signaling oscillations in presomitic mesoderm, FGFs/RTKs subcellular signaling compartments, and Signaling dynamics.

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Contents of the Textbook

  • Table of Contents
  • Title Page
  • Copyright
  • Contributors
  • Preface
  • Chapter One: Hedgehog signaling
  • Abstract
  • 1: Introduction
  • 2: The developmental genetics of Hh signaling in Drosophila
  • 3: The developmental genetics of Hh signaling in vertebrates
  • 4: Multiple protein interactions mediate reception of the Hh signal
  • 5: Structure and biosynthesis of Hh proteins
  • 6: Release and movement of Hh proteins from producing cells
  • 7: Reception of HH at the membrane: the role of Patched and Smoothened
  • 8: The intracellular response to Hh
  • 9: Concluding comments
  • Acknowledgments
  • References
  • Chapter Two: Different strategies by distinct Wnt-signaling pathways in activating a nuclear transcriptional response
  • Abstract
  • 1: Overview of Wnt-signaling pathways
  • 2: Induction of nuclear responses downstream of Wnt-signaling
  • 3: How does β-catenin get transported into the nucleus
  • 4: Concluding remarks
  • Acknowledgments
  • References
  • Chapter Three: Hippo signaling in cardiac fibroblasts during development, tissue repair, and fibrosis
  • Abstract
  • 1: Introduction
  • 2: Components of the Hippo pathway and their regulation
  • 3: The contribution of resident CFs to cardiac fibrosis
  • 4: Outstanding questions and future directions
  • 5: Conclusion
  • Acknowledgments
  • References
  • Chapter Four: Pulling back the curtain: The hidden functions of receptor tyrosine kinases in development
  • Abstract
  • 1: Introduction
  • 2: Receptor tyrosine kinase signaling
  • 3: Dismantling RTK signaling one pathway at a time
  • 4: Without canonical signaling, what novel functions are revealed?
  • 5: Conclusion
  • Acknowledgments
  • References
  • Chapter Five: Cellular and molecular mechanisms of EPH/EPHRIN signaling in evolution and development
  • Abstract
  • 1: Introduction
  • 2: EPH/EPHRIN function through an evolutionary lens
  • 3: Cellular mechanisms underlying EPH/EPHRIN-mediated cell sorting and boundary formation
  • 4: Nervous system development
  • 5: Craniofacial and musculoskeletal development
  • 6: Conclusions and perspectives
  • Acknowledgments
  • References
  • Chapter Six: Integrins, anchors and signal transducers of hematopoietic stem cells during development and in adulthood
  • Abstract
  • 1: Integrins
  • 2: A common origin of vascular and hematopoietic cells
  • 3: Involvement of integrins in the establishment of the hematopoietic system
  • 4: Contribution of integrin-mediated adhesion to life-long hematopoiesis
  • 5: Integrin-mediated mechanosensing in the HSPC niche
  • 6: Integrin-mediated support of leukemic stem cells
  • 7: Conclusions
  • Acknowledgments
  • References
  • Chapter Seven: Putting in the Erk: Growth factor signaling and mesoderm morphogenesis
  • Abstract
  • 1: Introduction
  • 2: The fates of vertebrate mesodermal populations marked by brachyury
  • 3: FGF expression in the mesoderm: An upstream cue for Erk-dependent gene induction
  • 4: Generation and interpretation of transient Erk signaling in vertebrate mesoderm
  • 5: The role of Erk signaling in initiating and sustaining brachyury expression
  • 6: A role for Erk and a brachyury homology in Drosophila mesoderm specification
  • 7: Moving mesoderm: Erk-dependent control of convergence and extension
  • 8: Erk regulation of epithelial-to-mesenchymal transition in the primitive streak
  • 9: A potential role for Erk signaling in mesodermal directed cell migration
  • 10: Open questions and new tools for Erk control over mesoderm specification and movement
  • Acknowledgments
  • References
  • Chapter Eight: Establishment and interpretation of NODAL and BMP signaling gradients in early vertebrate development
  • Abstract
  • 1: Introduction
  • 2: NODAL signaling
  • 3: BMP signaling
  • 4: Interactions between NODAL and BMP signaling
  • 5: Outlook
  • Acknowledgments
  • References
  • Chapter Nine: Signaling oscillations in embryonic development
  • Abstract
  • 1: Introduction
  • 2: Single-cell oscillation dynamics
  • 3: Tissue-wide oscillation dynamics
  • 4: Perspective
  • Acknowledgments
  • References
  • Chapter Ten: Parallels in signaling between development and regeneration in ectodermal organs
  • Abstract
  • 1: Introduction
  • 2: From signaling centers during development to stem cell regulated morphogenesis in the adult
  • 3: Shh
  • 4: Wnt
  • 5: Notch
  • 6: Yap/Taz
  • 7: Conclusion—The regenerative properties of the ectoderm
  • Acknowledgments

The Writers

Philippe M. Soriano, Ph.D. | The Pew Charitable Trusts

Philippe Soriano,is Professor of Cell, Developmental & Regenerative Biology and Professor of Oncological Sciences, Icahn School of Medicine at Mount Sinai, NY, USA

Proportions of Cell Signaling Pathways in Development PDF

  • No. of pages: 432
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: May 18, 2022
  • Imprint: Academic Press
  • eBook International Standard Book Number: 9780128170984
  • Hardcover International Standard Book Number: 9780128170977


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