Cancer as a Metabolic Disease PDF Download Book

Cancer as a Metabolic Disease PDF

Description of Cancer as a Metabolic Disease PDF

Cancer as a Metabolic Disease PDF: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg’s well-known theory that all cancer is a disease of energy metabolism.  However, Warburg did not link his theory to the “hallmarks of cancer” and thus his theory was discredited.  This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention.  Support for this position is derived from critical assessment of current cancer theories.  Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

Features of Cancer as a Metabolic Disease PDF

  • Origin of metastasis
  • New treatment strategies that target tumor cell energy metabolism, including the ketogenic diet
  • More effective prevention strategies in light of the metabolic origin of cancer
  • Case studies and perspectives from the point of view of physicians, patients, and caregivers

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Editorial Reviews

Review

“This book offers a refreshing perspective for anyone wanting to get a comprehensive background on the newer emerging interest in targeting cancer metabolism for therapy.”  (Doody’s, 11 January 2013)

“For the first time, an entire issue is being devoted to a review article based on a recent medical book. This is a departure from our usual format, but I think you will agree that this topic warrants the detailed treatment we have given it . . .This book should be required reading for all scientifically literate people who are involved in the cancer problem.”  (Advances in Cancer Treatment, 1 October 2012)

From the Inside Flap

A groundbreaking new approach to understanding, preventing, and treating cancer

Supported by evidence from more than 1,000 scientific and clinical studies, this groundbreaking book demonstrates that cancer is a metabolic disease and, more importantly, that it can be more effectively managed and prevented when it is recognized as such. Moreover, the book provides detailed evidence that the traditional view of cancer as a genetic disease has been largely responsible for the failure to develop effective therapies and preventive strategies.

Cancer as a Metabolic Disease reevaluates the origins of cancer based on the latest research findings as well as several decades of studies exploring the defects in tumor cell energy metabolism. Author Thomas Seyfried is a biochemical geneticist who has been investigating the lipid biochemistry of cancer for thirty years. In this book, he carefully establishes why approaching Cancer as a Metabolic Disease PDF leads to better understanding and management of all aspects of the disease, including inflammation, vascularization, cell death, drug resistance, and genomic instability. In addition, the book explores

From the Back Cover

A groundbreaking new approach to understanding, preventing, and treating cancer

Supported by evidence from more than 1,000 scientific and clinical studies, this groundbreaking book demonstrates that cancer is a metabolic disease and, more importantly, that it can be more effectively managed and prevented when it is recognized as such. Moreover, the book provides detailed evidence that the traditional view of cancer as a genetic disease has been largely responsible for the failure to develop effective therapies and preventive strategies.

Cancer as a Metabolic Disease reevaluates the origins of cancer based on the latest research findings as well as several decades of studies exploring the defects in tumor cell energy metabolism. Author Thomas Seyfried is a biochemical geneticist who has been investigating the lipid biochemistry of cancer for thirty years. In this book, he carefully establishes why approaching cancer as a metabolic disease leads to better understanding and management of all aspects of the disease, including inflammation, vascularization, cell death, drug resistance, and genomic instability. In addition, the book explores:

  • Origin of metastasis
  • New treatment strategies that target tumor cell energy metabolism, including the ketogenic diet
  • More effective prevention strategies in light of the metabolic origin of cancer
  • Case studies and perspectives from the point of view of physicians, patients, and caregivers

Throughout the book, tables, figures, and graphs summarize key information and clarify complex concepts. In addition, the renowned cancer biochemist Peter Pedersen from Johns Hopkins Medical School also provides a historical perspective on the importance of the information presented in his foreward to the book.

Cancer as a Metabolic Disease is essential reading for all cancer researchers and clinicians as well as public health professionals. By treating cancer as a metabolic disease, the book sets readers on a new, more promising path to understanding the origins of cancer and developing new, more effective strategies to treat and prevent it.

The Authors of Cancer as a Metabolic Disease PDF

Cancer as a Metabolic Disease PDF

THOMAS N. SEYFRIED, PhD, has taught and conducted research in the fields of neurogenetics, neurochemistry, and cancer for more than twenty-five years at Yale University and Boston College. He has published more than 150 scientific articles and book chapters and is on the editorial boards of Nutrition & Metabolism, Journal of Lipid Research, Neurochemical Research, and ASN Neuro.

Dimensions and Characteristics of Cancer as a Metabolic Disease PDF

    • Publisher ‏ : ‎ Wiley; 1st edition (June 26, 2012)
    • Language ‏ : ‎ English
    • Hardcover ‏ : ‎ 448 pages
    • International Standard Book Number-10 ‏ : ‎ 0470584920
    • International Standard Book Number-13 ‏ : ‎ 978-0470584927
    • Item Weight ‏ : ‎ 1.9 pounds
    • Dimensions ‏ : ‎ 6.4 x 1 x 9.3 inches
    • Best Sellers Rank: #71,825 in Books

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Top reviews

J.B. Pruss

August 13, 2018

If your oncologist is traditionally trained, they may have never been given this type of information. If you have cancer as a diagnosis you should try to read this book. It is very scientific and may be tough for the average person. Get the Keto for Cancer book by Miriam Kalamian , EdM, MS, CNS !!!! Education and understanding how to specifically use the Ketogenic Diet is key to extending your survival and making your Healthy and “Feel Good ” days increase. Buy this book for your Oncologist and help to increase the knowledge base that Diet can help extend life. Kalamian also recommends some resistance training to ensure your muscles are functioning as they should to have a healthy metabolism. It has made a huge difference for me and my Stage 4 breast cancer has stabilized. Mets to the liver and the bone are very scary. I highly recommend both books.
60 people found this helpful
Stephen Strum

September 1, 2012

I am a board-certified medical oncologist with 30 years experience in caring for cancer patients and another 20 years of research in cancer medicine dating back to 1963. Seyfried’s “Cancer as a Metabolic Disease” is the most significant book I have read in my 50 years in this field. It should be required reading of all cancer specialists, physicians in general, scientific researchers in the field of cancer and for medical students. I cannot overstate what a valuable contribution Thomas Seyfried has made in writing this masterpiece.
Stephen B. Strum, MD, FACP
Medical Oncologist, Member of ASCO (American Society of Clinical Oncology) since 1975
54
Dominic D’Agostino

July 1, 2012

Dr. Seyfried provides compelling evidence that cancer is a metabolic disease (NOT a genetic disease), and this has major implications for the treatment and prevention of cancer.

According to Otto Warburg’s theory of cancer, mitochondrial dysfunction is the origin of cancer. Dr. Seyfried has amassed extensive evidence to support Warburg’s theory and advances the idea that cancer arises from defects in energy metabolism (mitochondrial dysfunction), and that this metabolic dysfunction triggers genomic instability, activates oncogenes and inactivating tumor suppressor genes. The author does an incredible job at convincing the reader that healthy mitochondria are the ultimate tumor suppressor.

It’s clear that the strategy to treat cancer as a genetic disease is not working following metastasis of solid primary tumors, but this fuels the pharmaceutical industry. Enormous amounts of money are spent on large cancer genome projects, but this has not advanced our understanding or treatment of cancer as expected. The cancer genome project has actually created more confusion amongst cancer researchers, and this is very clear if one reads the literature. On the other hand, when cancer is viewed as a metabolic disease the strategies to treat and prevent cancer become incredibly simplistic and economical. For example, animals studies, case reports and anecdotal evidence demonstrate that metabolic therapies that lower blood glucose and elevate ketones will quickly reduce tumor growth, extend lifespan and in some cases cause complete remission. This strategy is effective because cancer cells are fueled by glucose and lack the ability to derive energy from ketones due to mitochondrial defects. Metabolic therapies exploit the mitochondrial defects associated with cancer by targeting glucose metabolism, reducing insulin and elevating ketones. These therapies are simple and include “therapeutic fasting”, calorie restricted ketogenic diets and relatively cheap and safe drugs that target glycolysis, insulin and other cancer-specific metabolic pathways. The information in this book is valuable to patients and supported by extensive references. This book is technical (in parts), but the author has the ability to describe complicated processes with elegant simplicity.

I read this book immediately after reading “The Secret History of the War on Cancer” and “The Emperor of All Maladies”. These are excellent books, but I found Dr. Seyfried’s book to be more informative and empowering because it gives the reader clear evidence for the cause of cancer and highly effective strategies to prevent and treat the disease.

I would recommend this book to all cancer researchers, oncologists and layman interested in understanding the origin, management and treatment of cancer as a metabolic disease. This book will also be an extremely valuable resource for patients diagnosed with cancer.
Dominic D’Agostino, PhD, University of South Florida50.

William H. Burling

January 24, 2014

There is no one like Thomas Seyfried. I borrowed his book from UCONN for 6 weeks to see if it was worth the $140 price. I bought two which is one month’s worth of food for my family. We sacrificed to own his book. The guy is a true scientist. Not proclaiming magic. Asking excellent questions. Providing experimental evidence. Addressing competing points of view. He is not into cancer research for the glory; just look at the basic research that has occupied his life which never gets to see the media.

There is no question that I distrust the MD who is trained to regurgitate and is prevented from pushing the frontiers of knowledge. We all need more PhDs to increase our understandings and to offer competing points of view to stimulate further investigation. Such a competing point of view exists in all science other than that offered by the medical industry which has consistently promoted conformance, not pursuit of knowledge. Just read Gary Taubes book, Good Calories, Bad Calories to appreciate this point of view.

Cancer as a Metabolic Disease PDF

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